(R)-methyl 3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)-2-(4-(trifluoromethyl)phenoxy)propanoate

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Chemical Name:(R)-methyl 3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)-2-(4-(trifluoromethyl)phenoxy)propanoate
CAS No.:1262547-56-7
Molecular Formula:C₃₁H₂₇F₃N₂O₅
Molecular Weight:564.561
Hs Code.:

Synonyms:(R)-methyl 3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)-2-(4-(trifluoromethyl)phenoxy)propanoate

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Chemical Property of (R)-methyl 3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)-2-(4-(trifluoromethyl)phenoxy)propanoate

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Technology Process of (R)-methyl 3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)-2-(4-(trifluoromethyl)phenoxy)propanoate

There total 19 articles about (R)-methyl 3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)-2-(4-(trifluoromethyl)phenoxy)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 402-45-9
4-hydroxybenzotrifluoride

: 1262547-45-4
(R)-methyl 2-hydroxy-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoate

: 1262547-56-7
(R)-methyl 3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)-2-(4-(trifluoromethyl)phenoxy)propanoate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In toluene; at 0 - 20 ℃; for 12h;
DOI:10.1016/j.ejmech.2011.05.028

Reference yield:

: 501031-61-4
2-(5-methyl-2-phenyloxazol-4-yl)acetaldehyde

: 1262547-56-7
(R)-methyl 3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)-2-(4-(trifluoromethyl)phenoxy)propanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1 h / -10 °C

1.2: 0.17 h / -10 °C

2.1: platinum(IV) oxide trihydrate; hydrogen / methanol / 12 h / 760.05 Torr

3.1: lithium hydroxide monohydrate / ethanol / 1 h / 20 °C

3.2: pH 3

4.1: triethylamine / tetrahydrofuran / 0.5 h / -78 - 0 °C

5.1: n-butyllithium / tetrahydrofuran; hexane

5.2: 0.5 h / -78 - 20 °C

6.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

6.2: 4 h / -78 °C

7.1: ethylmagnesium bromide / diethyl ether / 0.17 h / -10 °C

8.1: di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 12 h / 0 - 20 °C

With n-butyllithium; lithium hydroxide monohydrate; platinum(IV) oxide trihydrate; di-isopropyl azodicarboxylate; ethylmagnesium bromide; potassium tert-butylate; hydrogen; potassium hexamethylsilazane; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; toluene; 1.2: Horner-Wadsworth-Emmons olefination / 6.2: Davis asymmetric oxidation / 8.1: Mitsunobu reaction;
DOI:10.1016/j.ejmech.2011.05.028

Reference yield:

: 1262547-37-4
methyl 3-(2-(chloromethyl)benzo[d]oxazol-5-yl)propanoate

: 1262547-56-7
(R)-methyl 3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)-2-(4-(trifluoromethyl)phenoxy)propanoate

Guidance literature:: Multi-step reaction with 9 steps

1.1: N,N-dimethyl-formamide / 3 h / 150 °C

2.1: potassium tert-butylate / tetrahydrofuran / 1 h / -10 °C

2.2: 0.17 h / -10 °C

3.1: platinum(IV) oxide trihydrate; hydrogen / methanol / 12 h / 760.05 Torr

4.1: lithium hydroxide monohydrate / ethanol / 1 h / 20 °C

4.2: pH 3

5.1: triethylamine / tetrahydrofuran / 0.5 h / -78 - 0 °C

6.1: n-butyllithium / tetrahydrofuran; hexane

6.2: 0.5 h / -78 - 20 °C

7.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

7.2: 4 h / -78 °C

8.1: ethylmagnesium bromide / diethyl ether / 0.17 h / -10 °C

9.1: di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 12 h / 0 - 20 °C

With n-butyllithium; lithium hydroxide monohydrate; platinum(IV) oxide trihydrate; di-isopropyl azodicarboxylate; ethylmagnesium bromide; potassium tert-butylate; hydrogen; potassium hexamethylsilazane; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; N,N-dimethyl-formamide; toluene; 2.2: Horner-Wadsworth-Emmons olefination / 7.2: Davis asymmetric oxidation / 9.1: Mitsunobu reaction;
DOI:10.1016/j.ejmech.2011.05.028