(R)-methyl 2-hydroxy-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoate

Base Information

Chemical Name:(R)-methyl 2-hydroxy-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoate
CAS No.:1262547-45-4
Molecular Formula:C₂₄H₂₄N₂O₅
Molecular Weight:420.465
Hs Code.:

Synonyms:(R)-methyl 2-hydroxy-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-methyl 2-hydroxy-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoate

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Technology Process of (R)-methyl 2-hydroxy-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoate

There total 18 articles about (R)-methyl 2-hydroxy-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.5%

: 67-56-1
methanol

: 1262547-43-2
(R)-3-((R)-2-hydroxy-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoyl)-4-isopropyl oxazolidin-2-one

: 1262547-45-4
(R)-methyl 2-hydroxy-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoate

Guidance literature:: With ethylmagnesium bromide; In diethyl ether; at -10 ℃; for 0.166667h;
DOI:10.1016/j.ejmech.2011.05.028

Reference yield:

: 501031-61-4
2-(5-methyl-2-phenyloxazol-4-yl)acetaldehyde

: 1262547-45-4
(R)-methyl 2-hydroxy-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1 h / -10 °C

1.2: 0.17 h / -10 °C

2.1: platinum(IV) oxide trihydrate; hydrogen / methanol / 12 h / 760.05 Torr

3.1: lithium hydroxide monohydrate / ethanol / 1 h / 20 °C

3.2: pH 3

4.1: triethylamine / tetrahydrofuran / 0.5 h / -78 - 0 °C

5.1: n-butyllithium / tetrahydrofuran; hexane

5.2: 0.5 h / -78 - 20 °C

6.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

6.2: 4 h / -78 °C

7.1: ethylmagnesium bromide / diethyl ether / 0.17 h / -10 °C

With n-butyllithium; lithium hydroxide monohydrate; platinum(IV) oxide trihydrate; ethylmagnesium bromide; potassium tert-butylate; hydrogen; potassium hexamethylsilazane; triethylamine; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; 1.2: Horner-Wadsworth-Emmons olefination / 6.2: Davis asymmetric oxidation;
DOI:10.1016/j.ejmech.2011.05.028

Reference yield:

: 1262547-37-4
methyl 3-(2-(chloromethyl)benzo[d]oxazol-5-yl)propanoate

: 1262547-45-4
(R)-methyl 2-hydroxy-3-(2-(3-(5-methyl-2-phenyloxazol-4-yl)propyl)benzo[d]oxazol-5-yl)propanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: N,N-dimethyl-formamide / 3 h / 150 °C

2.1: potassium tert-butylate / tetrahydrofuran / 1 h / -10 °C

2.2: 0.17 h / -10 °C

3.1: platinum(IV) oxide trihydrate; hydrogen / methanol / 12 h / 760.05 Torr

4.1: lithium hydroxide monohydrate / ethanol / 1 h / 20 °C

4.2: pH 3

5.1: triethylamine / tetrahydrofuran / 0.5 h / -78 - 0 °C

6.1: n-butyllithium / tetrahydrofuran; hexane

6.2: 0.5 h / -78 - 20 °C

7.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

7.2: 4 h / -78 °C

8.1: ethylmagnesium bromide / diethyl ether / 0.17 h / -10 °C

With n-butyllithium; lithium hydroxide monohydrate; platinum(IV) oxide trihydrate; ethylmagnesium bromide; potassium tert-butylate; hydrogen; potassium hexamethylsilazane; triethylamine; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; N,N-dimethyl-formamide; 2.2: Horner-Wadsworth-Emmons olefination / 7.2: Davis asymmetric oxidation;
DOI:10.1016/j.ejmech.2011.05.028