(R)-2-(4-fluoro-3-methylphenoxy)-4-((3-(4-fluoro-3-methylphenyl)propyl)(methyl)amino)-N-hydroxybutanamide

Base Information

Chemical Name:(R)-2-(4-fluoro-3-methylphenoxy)-4-((3-(4-fluoro-3-methylphenyl)propyl)(methyl)amino)-N-hydroxybutanamide
CAS No.:1043450-61-8
Molecular Formula:C₂₂H₂₈F₂N₂O₃
Molecular Weight:406.473
Hs Code.:

Synonyms:(R)-2-(4-fluoro-3-methylphenoxy)-4-((3-(4-fluoro-3-methylphenyl)propyl)(methyl)amino)-N-hydroxybutanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-(4-fluoro-3-methylphenoxy)-4-((3-(4-fluoro-3-methylphenyl)propyl)(methyl)amino)-N-hydroxybutanamide

Chemical Property:

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Technology Process of (R)-2-(4-fluoro-3-methylphenoxy)-4-((3-(4-fluoro-3-methylphenyl)propyl)(methyl)amino)-N-hydroxybutanamide

There total 12 articles about (R)-2-(4-fluoro-3-methylphenoxy)-4-((3-(4-fluoro-3-methylphenyl)propyl)(methyl)amino)-N-hydroxybutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1043450-60-7
(S)-4-benzyl-3-((R)-2-(4-fluoro-3-methylphenoxy)-4-((3-(4-fluoro-3-methylphenyl)propyl)(methyl)amino)butanoyl)oxazolidin-2-one

: 1043450-61-8
(R)-2-(4-fluoro-3-methylphenoxy)-4-((3-(4-fluoro-3-methylphenyl)propyl)(methyl)amino)-N-hydroxybutanamide

Guidance literature:: With hydroxylamine; potassium cyanide; In tetrahydrofuran; methanol; water;

Reference yield:

: 1043450-40-3
2-(4-fluoro-3-methylphenoxy)acetyl chloride

: 1043450-61-8
(R)-2-(4-fluoro-3-methylphenoxy)-4-((3-(4-fluoro-3-methylphenyl)propyl)(methyl)amino)-N-hydroxybutanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -70 °C

1.2: 2 h / -70 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -70 °C

2.2: 1 h / -70 °C

3.1: ozone / dichloromethane / 0.5 h / -70 °C

3.2: 3 h / -70 - 20 °C

4.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 8 h / 20 °C

5.1: hydroxylamine / potassium cyanide / tetrahydrofuran; methanol; water

With n-butyllithium; hydroxylamine; sodium tris(acetoxy)borohydride; ozone; acetic acid; lithium hexamethyldisilazane; potassium cyanide; In tetrahydrofuran; methanol; hexane; dichloromethane; water; 1,2-dichloro-ethane;

Reference yield:

: 878662-33-0
ethyl 3-(4'-fluoro-3'-methylphenyl)propanal

: 1043450-61-8
(R)-2-(4-fluoro-3-methylphenoxy)-4-((3-(4-fluoro-3-methylphenyl)propyl)(methyl)amino)-N-hydroxybutanamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium cyanoborohydride / methanol / 2 h / 20 °C

2: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 8 h / 20 °C

3: hydroxylamine / potassium cyanide / tetrahydrofuran; methanol; water

With hydroxylamine; sodium tris(acetoxy)borohydride; sodium cyanoborohydride; acetic acid; potassium cyanide; In tetrahydrofuran; methanol; water; 1,2-dichloro-ethane;