(S)-4-benzyl-3-((R)-2-(4-fluoro-3-methylphenoxy)-4-((3-(4-fluoro-3-methylphenyl)propyl)(methyl)amino)butanoyl)oxazolidin-2-one

Base Information

Chemical Name:(S)-4-benzyl-3-((R)-2-(4-fluoro-3-methylphenoxy)-4-((3-(4-fluoro-3-methylphenyl)propyl)(methyl)amino)butanoyl)oxazolidin-2-one
CAS No.:1043450-60-7
Molecular Formula:C₃₂H₃₆F₂N₂O₄
Molecular Weight:550.646
Hs Code.:

Synonyms:(S)-4-benzyl-3-((R)-2-(4-fluoro-3-methylphenoxy)-4-((3-(4-fluoro-3-methylphenyl)propyl)(methyl)amino)butanoyl)oxazolidin-2-one

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Chemical Property of (S)-4-benzyl-3-((R)-2-(4-fluoro-3-methylphenoxy)-4-((3-(4-fluoro-3-methylphenyl)propyl)(methyl)amino)butanoyl)oxazolidin-2-one

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Technology Process of (S)-4-benzyl-3-((R)-2-(4-fluoro-3-methylphenoxy)-4-((3-(4-fluoro-3-methylphenyl)propyl)(methyl)amino)butanoyl)oxazolidin-2-one

There total 11 articles about (S)-4-benzyl-3-((R)-2-(4-fluoro-3-methylphenoxy)-4-((3-(4-fluoro-3-methylphenyl)propyl)(methyl)amino)butanoyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1043450-54-9
3-(4-Fluoro-3-methylphenyl)-N-methylpropan-1-amine

: 1043450-58-3
(R)-4-((S)-4-benzyl-2-oxooxazolidin-3-yl)-3-(4-fluoro-3-methylphenoxy)-4-oxobutanal

: 1043450-60-7
(S)-4-benzyl-3-((R)-2-(4-fluoro-3-methylphenoxy)-4-((3-(4-fluoro-3-methylphenyl)propyl)(methyl)amino)butanoyl)oxazolidin-2-one

Guidance literature:: 3-(4-Fluoro-3-methylphenyl)-N-methylpropan-1-amine; (R)-4-((S)-4-benzyl-2-oxooxazolidin-3-yl)-3-(4-fluoro-3-methylphenoxy)-4-oxobutanal; With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 8h;

With sodium hydroxide; In water; 1,2-dichloro-ethane;

Reference yield:

: 1043450-39-0
ethyl 2-(4-fluoro-3-methylphenoxy)acetate

: 1043450-60-7
(S)-4-benzyl-3-((R)-2-(4-fluoro-3-methylphenoxy)-4-((3-(4-fluoro-3-methylphenyl)propyl)(methyl)amino)butanoyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide; water / 1,4-dioxane / 0.5 h / 20 - 25 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 25 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -70 °C

3.2: 2 h / -70 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -70 °C

4.2: 1 h / -70 °C

5.1: ozone / dichloromethane / 0.5 h / -70 °C

5.2: 3 h / -70 - 20 °C

6.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 8 h / 20 °C

With potassium hydroxide; n-butyllithium; oxalyl dichloride; water; sodium tris(acetoxy)borohydride; ozone; acetic acid; lithium hexamethyldisilazane; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 1043450-52-7
(E)-Methyl 3-(4-fluoro-3-methylphenyl)acrylate

: 1043450-60-7
(S)-4-benzyl-3-((R)-2-(4-fluoro-3-methylphenoxy)-4-((3-(4-fluoro-3-methylphenyl)propyl)(methyl)amino)butanoyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 20 °C

2: diisobutylaluminium hydride / dichloromethane; cyclohexane / 0.5 h / -70 °C

3: sodium cyanoborohydride / methanol / 2 h / 20 °C

4: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 8 h / 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; sodium cyanoborohydride; acetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; cyclohexane; 1,2-dichloro-ethane;