C₁₀H₈N₂O₃

Base Information

• Chemical Name: C₁₀H₈N₂O₃
• CAS No.: 1147335-00-9
• Molecular Formula: C₁₀H₈N₂O₃
• Molecular Weight: 204.185
• Mol file: 1147335-00-9.mol

Synonyms:C₁₀H₈N₂O₃

Chemical Property of C₁₀H₈N₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₀H₈N₂O₃

There total 8 articles about C₁₀H₈N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3-(hydroxymethyl)-4-(p-tolyl)-1,2,5-oxadiazole 2-oxide (1147334-73-3) → C10H8N2O3 (1147335-00-9)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃;

Reference yield:

ethyl p-methylcinnamate (20511-20-0) → C10H8N2O3 (1147335-00-9)

Guidance literature:

Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / dichloromethane / 1 h / -70 - 20 °C

2: sodium nitrite; acetic acid / water / 20 °C

3: Dess-Martin periodane / dichloromethane / 20 °C

With diisobutylaluminium hydride; Dess-Martin periodane; acetic acid; sodium nitrite; In dichloromethane; water;

Reference yield:

4-methylcinnamyl alcohol (122058-30-4,1504-62-7) → C10H8N2O3 (1147335-00-9)

Guidance literature:

4-methylcinnamyl alcohol; With sodium nitrite; In acetic acid; at 25 ℃; Inert atmosphere;

With manganese(IV) oxide; In dichloromethane; at 25 ℃; Inert atmosphere;

DOI:10.1021/jm901021k

upstream raw materials:

4-methylcinnamyl alcohol

4-methylcinnamic acid

ethyl p-methylcinnamate

3-(hydroxymethyl)-4-(p-tolyl)-1,2,5-oxadiazole 2-oxide

Downstream raw materials:

C₁₀H₉N₃O₃

3-cyano-4-p-tolyl-1,2,5-oxadiazole 2-oxide