(E)-methyl 3-(2-((2-phenylaziridin-1-yl)sulfonyl)phenyl)acrylate

Base Information

Chemical Name:(E)-methyl 3-(2-((2-phenylaziridin-1-yl)sulfonyl)phenyl)acrylate
CAS No.:1452489-79-0
Molecular Formula:C₁₈H₁₇NO₄S
Molecular Weight:343.403
Hs Code.:

Synonyms:(E)-methyl 3-(2-((2-phenylaziridin-1-yl)sulfonyl)phenyl)acrylate

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Chemical Property of (E)-methyl 3-(2-((2-phenylaziridin-1-yl)sulfonyl)phenyl)acrylate

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Technology Process of (E)-methyl 3-(2-((2-phenylaziridin-1-yl)sulfonyl)phenyl)acrylate

There total 2 articles about (E)-methyl 3-(2-((2-phenylaziridin-1-yl)sulfonyl)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6
styrene

: 21416-94-4
methyl (E)-3-(2-sulfamoylphenyl)acrylate

: 1452489-79-0
(E)-methyl 3-(2-((2-phenylaziridin-1-yl)sulfonyl)phenyl)acrylate

Guidance literature:: With N-Bromosuccinimide; tetrakis(μ-caprolactamato)dirhodium(Rh-Rh); potassium carbonate; In dichloromethane; at 23 ℃; Schlenk technique; Inert atmosphere;
DOI:10.1021/ja4076716

Reference yield:

: methyl (E)-3-(2-(chlorosulfonyl)phenyl)acrylate

: 1452489-79-0
(E)-methyl 3-(2-((2-phenylaziridin-1-yl)sulfonyl)phenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonia / 1,4-dioxane / 0.5 h / 0 °C / Schlenk technique

2: potassium carbonate; N-Bromosuccinimide; tetrakis(μ-caprolactamato)dirhodium(Rh-Rh) / dichloromethane / 23 °C / Schlenk technique; Inert atmosphere

With N-Bromosuccinimide; tetrakis(μ-caprolactamato)dirhodium(Rh-Rh); ammonia; potassium carbonate; In 1,4-dioxane; dichloromethane;
DOI:10.1021/ja4076716

Reference yield: 43.0%

: 1452489-79-0
(E)-methyl 3-(2-((2-phenylaziridin-1-yl)sulfonyl)phenyl)acrylate

: 126403-71-2
p-tolylzinc bromide

: 1452489-60-9
methyl (E)-3-(2-(N-(2-phenyl-2-(p-tolyl)ethyl)sulfamoyl)phenyl)acrylate

Guidance literature:: With nickel(II) bromide dimethoxyethane; lithium chloride; In tetrahydrofuran; hexane; at 23 ℃; for 12h; regioselective reaction; Schlenk technique; Inert atmosphere;
DOI:10.1021/ja4076716