2-[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-[(3'-{[1-piperazinyl]methyl}-3-biphenylyl)methyl]acetamide trifluoroacetate

Base Information

Chemical Name:2-[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-[(3'-{[1-piperazinyl]methyl}-3-biphenylyl)methyl]acetamide trifluoroacetate
CAS No.:1179344-36-5
Molecular Formula:C₂HF₃O₂*C₃₅H₄₅N₇O₂
Molecular Weight:709.812
Hs Code.:

2-[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-[(3'-{[1-piperazinyl]methyl}-3-biphenylyl)methyl]acetamide trifluoroacetate

Synonyms:2-[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-[(3'-{[1-piperazinyl]methyl}-3-biphenylyl)methyl]acetamide trifluoroacetate

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Chemical Property of 2-[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-[(3'-{[1-piperazinyl]methyl}-3-biphenylyl)methyl]acetamide trifluoroacetate

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Technology Process of 2-[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-[(3'-{[1-piperazinyl]methyl}-3-biphenylyl)methyl]acetamide trifluoroacetate

There total 5 articles about 2-[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-[(3'-{[1-piperazinyl]methyl}-3-biphenylyl)methyl]acetamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₀H₅₃N₇O₄

: 76-05-1
trifluoroacetic acid

: 1179344-36-5
2-[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-[(3'-{[1-piperazinyl]methyl}-3-biphenylyl)methyl]acetamide trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 865314-28-9
(3-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)phenyl)boronic acid

: 1179344-36-5
2-[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-[(3'-{[1-piperazinyl]methyl}-3-biphenylyl)methyl]acetamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: water; potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.25 h / 150 °C / Microwave irradiation

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 15 h / 20 °C

3: dichloromethane / 0.5 h / 20 °C

With water; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; 1: Suzuki Coupling;

Reference yield:

: 87199-16-4
3-Formylphenylboronic acid

: 1179344-36-5
2-[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-[(3'-{[1-piperazinyl]methyl}-3-biphenylyl)methyl]acetamide trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tris(acetoxy)borohydride / dichloromethane / 17 h / 20 °C

2: water; potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.25 h / 150 °C / Microwave irradiation

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 15 h / 20 °C

4: dichloromethane / 0.5 h / 20 °C

With water; sodium tris(acetoxy)borohydride; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; 2: Suzuki Coupling;