7-CHLORO-1-PHENYL-3,4-DIHYDRO-ISOQUINOLINE

Base Information

• Chemical Name: 7-CHLORO-1-PHENYL-3,4-DIHYDRO-ISOQUINOLINE
• CAS No.: 104576-30-9
• Molecular Formula: C15H12 Cl N
• Molecular Weight: 241.72
• Hs Code.: 2933499090
• Mol file: 104576-30-9.mol

Synonyms:7-Chloro-1-phenyl-3,4-dihydroisoquinoline

Chemical Property of 7-CHLORO-1-PHENYL-3,4-DIHYDRO-ISOQUINOLINE

Chemical Property:

• PSA: 12.36000
• LogP: 3.16910

Purity/Quality:

98.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-CHLORO-1-PHENYL-3,4-DIHYDRO-ISOQUINOLINE

There total 12 articles about 7-CHLORO-1-PHENYL-3,4-DIHYDRO-ISOQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

→ 1-phenyl-7-chloro-3,4-dihydroisoquinoline (104576-30-9)

Guidance literature:

With trichlorophosphate; In 5,5-dimethyl-1,3-cyclohexadiene; for 2h; Reflux;

Reference yield: 76.0%

7-chloro-1-phenyl-1,2,3,4-tetrahydroisoquinoline (741615-46-3) → 1-phenyl-7-chloro-3,4-dihydroisoquinoline (104576-30-9) + C15H10ClN

Guidance literature:

With potassium phosphate tribasic trihydrate; 5%-palladium/activated carbon; oxygen; In acetonitrile; at 60 ℃; chemoselective reaction; Green chemistry;

DOI:10.1016/S1872-2067(14)60243-6

Reference yield: 75.0%

7-chloro-1-phenyl-1,2,3,4-tetrahydroisoquinoline (741615-46-3) → 1-phenyl-7-chloro-3,4-dihydroisoquinoline (104576-30-9)

Guidance literature:

With N,N-dimethyl-formamide; at 100 ℃; for 24h; chemoselective reaction; Schlenk technique; Green chemistry;

DOI:10.1016/j.tetlet.2016.01.008

upstream raw materials:

1-(benzoylamino)-2-(4-chlorophenyl)ethane

benzoyl chloride

4-chlorophenylethylamine

7-chloro-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Downstream raw materials:

N-acetyl-7-chloro-1-phenyl-1,2-dihydroisoquinoline

7-chloro-1-phenyl-1,2,3,4-tetrahydroisoquinoline

2-acetyl-1,1,5-trichloro-3-phenyl-1a,2,3,7b-tetrahydro-1H-cyclopropisoquinoline

1-((1aR,3S,7bS)-1,1-Dibromo-5-chloro-3-phenyl-1,1a,3,7b-tetrahydro-2-aza-cyclopropa[a]naphthalen-2-yl)-ethanone

Refernces

• 1、 Kurouchi, Hiroaki. "Enhancement of the carbamate activation rate enabled syntheses of tetracyclic benzolactams: 8-oxoberbines and their 5- And 7-membered C-ring homologues". supporting information. p. 653 - 658. Retrieved 2021/02/06.
• 2、 -. "Aromatic ring or fused heterocycle linked 3,4-dihydroisoquinoline conjugated structure compound and application thereof". Paragraph 0028; 0054-0056. . Retrieved 2016/12/01.