741615-46-3

Upstream product

• 3418-95-9 1-(benzoylamino)-2-(4-chlorophenyl)ethane 
• 104576-30-9 1-phenyl-7-chloro-3,4-dihydroisoquinoline 
• 98-88-4 benzoyl chloride 
• 156-41-2 4-chlorophenylethylamine 

Downstream Products

• 104576-30-9 1-phenyl-7-chloro-3,4-dihydroisoquinoline 

Relevant academic research and scientific papers

Enhancement of the carbamate activation rate enabled syntheses of tetracyclic benzolactams: 8-oxoberbines and their 5- And 7-membered C-ring homologues

A route to the direct amidation of aromatic-ring-tetheredN-carbamoyl tetrahydroisoquinoline substrates was developed. This route enabled general access to 8-oxoberberines and their 5- and 7- membered C-ring homologues. It overcomes the undesired tandem side-reactions that result in the destruction of the isoquinoline backbone, which inevitably occurred under our previously reported superacidic carbamate activation method.