2-[2,4-Dioxo-5-phenyl-3-(4,5,6,7-tetrahydro-1-benzyl-1H-indazol-3-ylmethyl)-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-(4-methoxyphenyl)-acetamide

Base Information

• Chemical Name: 2-[2,4-Dioxo-5-phenyl-3-(4,5,6,7-tetrahydro-1-benzyl-1H-indazol-3-ylmethyl)-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-(4-methoxyphenyl)-acetamide
• CAS No.: 174180-79-1
• Molecular Formula: C₄₂H₄₃N₅O₄
• Molecular Weight: 681.835
• Mol file: 174180-79-1.mol

Synonyms:2-[2,4-Dioxo-5-phenyl-3-(4,5,6,7-tetrahydro-1-benzyl-1H-indazol-3-ylmethyl)-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-(4-methoxyphenyl)-acetamide

Chemical Property of 2-[2,4-Dioxo-5-phenyl-3-(4,5,6,7-tetrahydro-1-benzyl-1H-indazol-3-ylmethyl)-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-(4-methoxyphenyl)-acetamide

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2,4-Dioxo-5-phenyl-3-(4,5,6,7-tetrahydro-1-benzyl-1H-indazol-3-ylmethyl)-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-(4-methoxyphenyl)-acetamide

There total 10 articles about 2-[2,4-Dioxo-5-phenyl-3-(4,5,6,7-tetrahydro-1-benzyl-1H-indazol-3-ylmethyl)-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-(4-methoxyphenyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

water (7732-18-5) + 2-(2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl)-N-isopropyl-N-(4-methoxy-phenyl)-acetamide (174180-45-1) + 1-Benzyl-3-bromomethyl-4,5,6,7-tetrahydro-1H-indazole (174180-38-2) → 2-[2,4-Dioxo-5-phenyl-3-(4,5,6,7-tetrahydro-1-benzyl-1H-indazol-3-ylmethyl)-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-(4-methoxyphenyl)-acetamide (174180-79-1)

Guidance literature:

In tetrahydrofuran; hexane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

4-(isopropylamino)anisole (16495-67-3) → 2-[2,4-Dioxo-5-phenyl-3-(4,5,6,7-tetrahydro-1-benzyl-1H-indazol-3-ylmethyl)-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-(4-methoxyphenyl)-acetamide (174180-79-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / Et₃N / CH₂Cl₂ / Ambient temperature

2: 75 percent / K₂CO₃ / dimethylformamide / 16 h / 60 °C

3: 60 percent / tetrahydrofuran / 20 h / Ambient temperature

4: 1.) NaN(TMS)2 / 1.) THF, DMF, 0 deg C, 5 min, 2.) THF, DMF, RT, 3 h

With sodium hexamethyldisilazane; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm970265x

Reference yield:

benzyl bromide (100-39-0) → 2-[2,4-Dioxo-5-phenyl-3-(4,5,6,7-tetrahydro-1-benzyl-1H-indazol-3-ylmethyl)-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-(4-methoxyphenyl)-acetamide (174180-79-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.05 g / K₂CO₃ / dimethylformamide / 16 h / 60 °C

2: 740 mg / LiAlH₄ / tetrahydrofuran / 1.5 h / 20 - 50 °C

3: 39 percent / PPh₃, Br₂ / CCl₄ / 1.5 h / Ambient temperature

4: 1.) NaN(TMS)2 / 1.) THF, DMF, 0 deg C, 5 min, 2.) THF, DMF, RT, 3 h

With lithium aluminium tetrahydride; bromine; sodium hexamethyldisilazane; potassium carbonate; triphenylphosphine; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm970265x

upstream raw materials:

2-(2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl)-N-isopropyl-N-(4-methoxy-phenyl)-acetamide

1-Benzyl-3-bromomethyl-4,5,6,7-tetrahydro-1H-indazole

4-(isopropylamino)anisole

benzyl bromide