(3-(Benzyloxy)phenyl)methanamine

Base Information

• Chemical Name: (3-(Benzyloxy)phenyl)methanamine
• CAS No.: 104566-43-0
• Molecular Formula: C14H15 N O
• Molecular Weight: 213.279
• Hs Code.: 2922299090
• DSSTox Substance ID: DTXSID60451731
• Wikidata: Q82271912
• Mol file: 104566-43-0.mol

Synonyms:(3-(BENZYLOXY)PHENYL)METHANAMINE;104566-43-0;3-Benzyloxybenzylamine;[3-(benzyloxy)phenyl]methanamine;(3-phenylmethoxyphenyl)methanamine;1-[3-(benzyloxy)phenyl]methanamine;3-Benzyloxy-benzylamine;3-(Benzyloxy)benzyl]amine;[3-(benzyloxy)benzyl]amine;SCHEMBL538599;(3-benzyloxyphenyl)methylamine;DTXSID60451731;WAMBEHWAKBRTGT-UHFFFAOYSA-N;BBL030853;MFCD07786725;STK899018;AKOS000134047;SB79089;NCGC00338251-01;BS-14061;BB 0243002;CS-0205587;FT-0683179;EN300-42117;AB01331584-02

Chemical Property of (3-(Benzyloxy)phenyl)methanamine

Chemical Property:

• PSA: 35.25000
• LogP: 4.22660
• Storage Temp.: 2-8°C
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 213.115364102
• Heavy Atom Count: 16
• Complexity: 189

Purity/Quality:

98%min ^*data from raw suppliers

(3-(Benzyloxy)phenyl)methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CC=CC(=C2)CN

Technology Process of (3-(Benzyloxy)phenyl)methanamine

There total 13 articles about (3-(Benzyloxy)phenyl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-(azidomethyl)-3-(benzyloxy)benzene (440105-49-7) → [3-(benzyloxy)phenyl]methanamine (104566-43-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -70 - 0 ℃; for 1h; Inert atmosphere;

Reference yield: 88.0%

4-cyano-2-benzyloxypyridine (61147-43-1) → [3-(benzyloxy)phenyl]methanamine (104566-43-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 3h;

Reference yield: 82.0%

(3-benzyloxybenzyl) iminodicarboxylic acid di-tert-butyl ester → [3-(benzyloxy)phenyl]methanamine (104566-43-0)

Guidance literature:

(3-benzyloxybenzyl) iminodicarboxylic acid di-tert-butyl ester; With trifluoroacetic acid; at 0 ℃; for 0.5h;

With sodium hydrogencarbonate; In water;

upstream raw materials:

3-(benzyloxy)benzaldehyde oxime

1-(azidomethyl)-3-(benzyloxy)benzene

(3-(benzyloxy)phenyl)methanol

3-Benzyloxybenzaldehyde

Downstream raw materials:

(R)-2-[(tert-butoxycarbonyl)amino]-4-(methylmercapto)-N-[3-(benzyloxy)benzyl]butyramide

diethyl 1-(3-benzyloxybenzyl)-1,4-dihydro-4-phenyl-pyridine-3,5-dicarboxylate

N-(3-benzyloxyphenyl)methyl-2-aminonicotinic acid amide

N-[3-(benzyloxy)benzyl]formamide

Refernces

• 1、 -. "HETEROCYCLIC SULFONAMIDE DERIVATIVE AND MEDICINE COMPRISING SAME". Paragraph 0405; 0406. . Retrieved 2016/12/01.
• 2、 Banfi, Luca,Basso, Andrea,Giardini, Lorenzo,Riva, Renata,Rocca, Valeria,Guanti, Giuseppe. "Tandem Ugi MCR/mitsunobu cyclization as a short, protecting-group-free route to benzoxazinones with four diversity points". experimental part. p. 100 - 109. Retrieved 2011/03/21.