(R)-2-[(tert-butoxycarbonyl)amino]-4-(methylmercapto)-N-[3-(benzyloxy)benzyl]butyramide

Base Information

Chemical Name:(R)-2-[(tert-butoxycarbonyl)amino]-4-(methylmercapto)-N-[3-(benzyloxy)benzyl]butyramide
CAS No.:440105-50-0
Molecular Formula:C₂₄H₃₂N₂O₄S
Molecular Weight:444.595
Hs Code.:

Synonyms:(R)-2-[(tert-butoxycarbonyl)amino]-4-(methylmercapto)-N-[3-(benzyloxy)benzyl]butyramide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-[(tert-butoxycarbonyl)amino]-4-(methylmercapto)-N-[3-(benzyloxy)benzyl]butyramide

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Technology Process of (R)-2-[(tert-butoxycarbonyl)amino]-4-(methylmercapto)-N-[3-(benzyloxy)benzyl]butyramide

There total 4 articles about (R)-2-[(tert-butoxycarbonyl)amino]-4-(methylmercapto)-N-[3-(benzyloxy)benzyl]butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 5241-66-7
(R)-N-(tert-butoxycarbonyl)methionine

: 104566-43-0
[3-(benzyloxy)phenyl]methanamine

: 440105-50-0
(R)-2-[(tert-butoxycarbonyl)amino]-4-(methylmercapto)-N-[3-(benzyloxy)benzyl]butyramide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 18h;
DOI:10.1021/jm010531d

Reference yield:

: 104566-43-0
[3-(benzyloxy)phenyl]methanamine

: 440105-50-0
(R)-2-[(tert-butoxycarbonyl)amino]-4-(methylmercapto)-N-[3-(benzyloxy)benzyl]butyramide

Guidance literature:: In dichloromethane;

Reference yield:

: 1700-30-7
(3-(benzyloxy)phenyl)methanol

: 440105-50-0
(R)-2-[(tert-butoxycarbonyl)amino]-4-(methylmercapto)-N-[3-(benzyloxy)benzyl]butyramide

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / diphenylphosphoryl azide; DBU / toluene / 18 h / 20 °C

2: 87 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

3: 98 percent / PyBOP; DIEA / CH₂Cl₂ / 18 h

With lithium aluminium tetrahydride; diphenylphosphoranyl azide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jm010531d