Technology Process of PEG-Pr-TAM-2Li-Me-3,2-HOPO
There total 10 articles about PEG-Pr-TAM-2Li-Me-3,2-HOPO which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
water; acetic acid;
at 20 ℃;
for 240h;
DOI:10.1021/ja201511u
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium fluoride; 18-crown-6 ether; triethylamine / N,N-dimethyl-formamide / 24 h / Inert atmosphere
2.1: toluene-4-sulfonic acid / dichloromethane; acetonitrile
3.1: triethylamine / dichloromethane / 5 h
4.1: lithium hydroxide / methanol; water / 48 h / 20 °C
4.2: pH 2
5.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 4 h / Inert atmosphere; Cooling with ice
6.1: dichloromethane / 5 h / 20 °C / Inert atmosphere
7.1: hydrogenchloride / water; acetic acid / 240 h / 20 °C
With
hydrogenchloride; dmap; potassium fluoride; 18-crown-6 ether; toluene-4-sulfonic acid; triethylamine; dicyclohexyl-carbodiimide; lithium hydroxide;
In
methanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja201511u
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: thionyl chloride; N,N-dimethyl-formamide / benzene / 20 °C
2.1: triethylamine / dichloromethane / 5 h
3.1: lithium hydroxide / methanol; water / 48 h / 20 °C
3.2: pH 2
4.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 4 h / Inert atmosphere; Cooling with ice
5.1: dichloromethane / 5 h / 20 °C / Inert atmosphere
6.1: hydrogenchloride / water; acetic acid / 240 h / 20 °C
With
hydrogenchloride; dmap; thionyl chloride; triethylamine; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; lithium hydroxide;
In
methanol; dichloromethane; water; acetic acid; benzene;
DOI:10.1021/ja201511u
