PEG-Pr-TAM-2Li-Me-3,2-HOPO(Bn)3

Base Information

Chemical Name:PEG-Pr-TAM-2Li-Me-3,2-HOPO(Bn)3
CAS No.:1297532-54-7
Molecular Formula:C₄₉H₅₇N₅O₁₁
Molecular Weight:892.018
Hs Code.:

Synonyms:PEG-Pr-TAM-2Li-Me-3,2-HOPO(Bn)3

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of PEG-Pr-TAM-2Li-Me-3,2-HOPO(Bn)3

Chemical Property:

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Technology Process of PEG-Pr-TAM-2Li-Me-3,2-HOPO(Bn)3

There total 9 articles about PEG-Pr-TAM-2Li-Me-3,2-HOPO(Bn)3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1297532-26-3
PEG-Boc-(Fmoc)-L-DAP

: 1297532-54-7
PEG-Pr-TAM-2Li-Me-3,2-HOPO(Bn)3

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium fluoride; 18-crown-6 ether; triethylamine / N,N-dimethyl-formamide / 24 h / Inert atmosphere

2.1: toluene-4-sulfonic acid / dichloromethane; acetonitrile

3.1: triethylamine / dichloromethane / 5 h

4.1: lithium hydroxide / methanol; water / 48 h / 20 °C

4.2: pH 2

5.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 4 h / Inert atmosphere; Cooling with ice

6.1: dichloromethane / 5 h / 20 °C / Inert atmosphere

With dmap; potassium fluoride; 18-crown-6 ether; toluene-4-sulfonic acid; triethylamine; dicyclohexyl-carbodiimide; lithium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja201511u

Reference yield:

: TAM-acid-methyl ester(Bn)2

: 1297532-54-7
PEG-Pr-TAM-2Li-Me-3,2-HOPO(Bn)3

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / benzene / 20 °C

2.1: triethylamine / dichloromethane / 5 h

3.1: lithium hydroxide / methanol; water / 48 h / 20 °C

3.2: pH 2

4.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 4 h / Inert atmosphere; Cooling with ice

5.1: dichloromethane / 5 h / 20 °C / Inert atmosphere

With dmap; thionyl chloride; triethylamine; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; lithium hydroxide; In methanol; dichloromethane; water; benzene;
DOI:10.1021/ja201511u

Reference yield:

: C₂₄H₃₄N₄O₇

: 1297532-54-7
PEG-Pr-TAM-2Li-Me-3,2-HOPO(Bn)3

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 5 h

2.1: lithium hydroxide / methanol; water / 48 h / 20 °C

2.2: pH 2

3.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 4 h / Inert atmosphere; Cooling with ice

4.1: dichloromethane / 5 h / 20 °C / Inert atmosphere

With dmap; triethylamine; dicyclohexyl-carbodiimide; lithium hydroxide; In methanol; dichloromethane; water;
DOI:10.1021/ja201511u