N-(2-aminoethyl)-2-(6-(2,4-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide hydrochloride

Base Information

Chemical Name:N-(2-aminoethyl)-2-(6-(2,4-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide hydrochloride
CAS No.:1435472-73-3
Molecular Formula:C₁₆H₂₀N₄O₄S
Molecular Weight:364.425
Hs Code.:

Synonyms:N-(2-aminoethyl)-2-(6-(2,4-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide hydrochloride

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Chemical Property of N-(2-aminoethyl)-2-(6-(2,4-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide hydrochloride

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Technology Process of N-(2-aminoethyl)-2-(6-(2,4-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide hydrochloride

There total 5 articles about N-(2-aminoethyl)-2-(6-(2,4-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1435472-92-6
tert-butyl (2-(2-(6-(2,4-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)ethyl)carbamate

: 1435472-73-3
N-(2-aminoethyl)-2-(6-(2,4-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide hydrochloride

Guidance literature:: With acetyl chloride; In ethanol; at 50 ℃; for 1h;
DOI:10.1021/acs.jmedchem.5b00963

Reference yield:

: 1435472-90-4
(Z)-methyl 3-(2,4-dimethoxyphenyl)-3-((2-ethoxy-2-oxoethyl)amino)acrylate

: 1435472-73-3
N-(2-aminoethyl)-2-(6-(2,4-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 2-methyltetrahydrofuran / 18 h / 110 °C / Inert atmosphere

2: sodium hydroxide / methanol / 3 h / 35 °C

3: pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / N,N-dimethyl-formamide / 5 h / 0 - 20 °C / Inert atmosphere

4: acetyl chloride / ethanol / 1 h / 50 °C

With pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; acetyl chloride; sodium hydroxide; In 2-methyltetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.5b00963

Reference yield:

: 1435469-78-5
ethyl 2-(6-(2,4-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetate

: 1435472-73-3
N-(2-aminoethyl)-2-(6-(2,4-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / methanol / 3 h / 35 °C

2: pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / N,N-dimethyl-formamide / 5 h / 0 - 20 °C / Inert atmosphere

3: acetyl chloride / ethanol / 1 h / 50 °C

With pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; acetyl chloride; sodium hydroxide; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.5b00963