ethyl 2-(6-(2,4-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetate

Base Information

Chemical Name:ethyl 2-(6-(2,4-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetate
CAS No.:1435469-78-5
Molecular Formula:C₁₆H₁₈N₂O₅S
Molecular Weight:350.395
Hs Code.:

Synonyms:ethyl 2-(6-(2,4-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetate

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Chemical Property of ethyl 2-(6-(2,4-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetate

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Technology Process of ethyl 2-(6-(2,4-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetate

There total 3 articles about ethyl 2-(6-(2,4-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 2290-65-5
trimethylsilyl isothiocyanate

: 1435472-90-4
(Z)-methyl 3-(2,4-dimethoxyphenyl)-3-((2-ethoxy-2-oxoethyl)amino)acrylate

: 1435469-78-5
ethyl 2-(6-(2,4-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetate

Guidance literature:: In 2-methyltetrahydrofuran; at 110 ℃; for 18h; Inert atmosphere;

Reference yield:

: 676348-64-4
methyl 3-(2,4-dimethoxyphenyl)-3-oxopropanoate

: 1435469-78-5
ethyl 2-(6-(2,4-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; acetic acid / ethanol / 18 h / 100 °C

2: 2-methyltetrahydrofuran / 18 h / 110 °C / Inert atmosphere

With acetic acid; triethylamine; In 2-methyltetrahydrofuran; ethanol;

Reference yield:

: 829-20-9
2',4'-dimethoxyacetophenone

: 1435469-78-5
ethyl 2-(6-(2,4-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / tetrahydrofuran; tert-butyl methyl ether / 20 °C / Inert atmosphere

2: triethylamine; acetic acid / ethanol / 18 h / 100 °C

3: 2-methyltetrahydrofuran / 18 h / 110 °C / Inert atmosphere

With potassium tert-butylate; acetic acid; triethylamine; In tetrahydrofuran; 2-methyltetrahydrofuran; ethanol; tert-butyl methyl ether;