(2R,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylic acid 1,2-bis(phenylmethyl) ester

Base Information

Chemical Name:(2R,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylic acid 1,2-bis(phenylmethyl) ester
CAS No.:142776-07-6
Molecular Formula:C₂₀H₂₁NO₅
Molecular Weight:355.39
Hs Code.:

Synonyms:(2R,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylic acid 1,2-bis(phenylmethyl) ester

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Chemical Property of (2R,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylic acid 1,2-bis(phenylmethyl) ester

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Technology Process of (2R,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylic acid 1,2-bis(phenylmethyl) ester

There total 5 articles about (2R,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylic acid 1,2-bis(phenylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-39-0
benzyl bromide

: 130930-25-5
(R,R)-4-hydroxy-1-(benzyloxycarbonyl)pyrrolidine-2-carboxylic acid

: 142776-07-6
(2R,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylic acid 1,2-bis(phenylmethyl) ester

Guidance literature:: With tetra-(n-butyl)ammonium iodide; triethylamine; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1021/jm900598m

Reference yield:

: 100-39-0
benzyl bromide

: 197079-48-4
trans-N-(Benzyloxycarbonyl)-4-hydroxy-L-proline

: 13500-53-3,113039-54-6,132592-07-5,142776-07-6
(2S)-dibenzyl-4-hydroxypyrrolidine-1,2-dicarboxylate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 18h;
DOI:10.1039/c5dt04969e

Reference yield:

: 51-35-4,913000-57-4,30724-02-8
4-hydroxyproline

: 13500-53-3,113039-54-6,132592-07-5,142776-07-6
(2S)-dibenzyl-4-hydroxypyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / acetone; water / 2 h / 20 °C

2: triethylamine / tetrahydrofuran / 18 h / 20 °C

With sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; water; acetone;
DOI:10.1039/c5dt04969e