1-[(S)-1-(4-bromo-phenyl)-ethylamino]-3-cyclopropylmethyl-5-methyl-hex-5-en-3-ol

Base Information

Chemical Name:1-[(S)-1-(4-bromo-phenyl)-ethylamino]-3-cyclopropylmethyl-5-methyl-hex-5-en-3-ol
CAS No.:1352754-35-8
Molecular Formula:C₁₉H₂₈BrNO
Molecular Weight:366.341
Hs Code.:

Synonyms:1-[(S)-1-(4-bromo-phenyl)-ethylamino]-3-cyclopropylmethyl-5-methyl-hex-5-en-3-ol

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Chemical Property of 1-[(S)-1-(4-bromo-phenyl)-ethylamino]-3-cyclopropylmethyl-5-methyl-hex-5-en-3-ol

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Technology Process of 1-[(S)-1-(4-bromo-phenyl)-ethylamino]-3-cyclopropylmethyl-5-methyl-hex-5-en-3-ol

There total 5 articles about 1-[(S)-1-(4-bromo-phenyl)-ethylamino]-3-cyclopropylmethyl-5-methyl-hex-5-en-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 1352754-34-7
4-[(S)-1-(4-bromo-phenyl)-ethylamino]-1-cyclopropyl-butan-2-one

: 5674-01-1
2-methylallylmagnesium chloride

: 1352754-35-8
1-[(S)-1-(4-bromo-phenyl)-ethylamino]-3-cyclopropylmethyl-5-methyl-hex-5-en-3-ol

Guidance literature:: 4-[(S)-1-(4-bromo-phenyl)-ethylamino]-1-cyclopropyl-butan-2-one; 2-methylallylmagnesium chloride; In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; water;

Reference yield:

: 5239-82-7
cyclopropylacetic acid

: 1352754-35-8
1-[(S)-1-(4-bromo-phenyl)-ethylamino]-3-cyclopropylmethyl-5-methyl-hex-5-en-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; HATU / dichloromethane / 3 h / 0 - 20 °C

2: tetrahydrofuran / 6 h / -78 - 20 °C / Inert atmosphere

3: methanol / 0.17 h / 80 °C

4: tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

With triethylamine; HATU; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 27298-97-1
(S)-1-(4-bromophenyl)ethylamine

: 1352754-35-8
1-[(S)-1-(4-bromo-phenyl)-ethylamino]-3-cyclopropylmethyl-5-methyl-hex-5-en-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 0.17 h / 80 °C

2: tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

In tetrahydrofuran; methanol;