methyl 3-((1-(5-(3-methyl-5-phenylbenzofuran-2-carboxamido)pyrimidin-2-yl)piperidin-4-yl)methoxy)benzoate

Base Information

Chemical Name:methyl 3-((1-(5-(3-methyl-5-phenylbenzofuran-2-carboxamido)pyrimidin-2-yl)piperidin-4-yl)methoxy)benzoate
CAS No.:1275992-11-4
Molecular Formula:C₃₄H₃₂N₄O₅
Molecular Weight:576.652
Hs Code.:

Synonyms:methyl 3-((1-(5-(3-methyl-5-phenylbenzofuran-2-carboxamido)pyrimidin-2-yl)piperidin-4-yl)methoxy)benzoate

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Chemical Property of methyl 3-((1-(5-(3-methyl-5-phenylbenzofuran-2-carboxamido)pyrimidin-2-yl)piperidin-4-yl)methoxy)benzoate

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Technology Process of methyl 3-((1-(5-(3-methyl-5-phenylbenzofuran-2-carboxamido)pyrimidin-2-yl)piperidin-4-yl)methoxy)benzoate

There total 12 articles about methyl 3-((1-(5-(3-methyl-5-phenylbenzofuran-2-carboxamido)pyrimidin-2-yl)piperidin-4-yl)methoxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1155149-68-0
3-methyl-5-phenylbenzofuran-2-carboxylic acid

: 1275993-22-0
methyl 3-((1-(5-aminopyrimidin-2-yl)piperidin-4-yl)methoxy)benzoate

: 1275992-11-4
methyl 3-((1-(5-(3-methyl-5-phenylbenzofuran-2-carboxamido)pyrimidin-2-yl)piperidin-4-yl)methoxy)benzoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

Reference yield:

: 1275993-20-8
methyl 3-((1-(5-nitropyrimidin-2-yl)piperidin-4-yl)methoxy)benzoate

: 1275992-11-4
methyl 3-((1-(5-(3-methyl-5-phenylbenzofuran-2-carboxamido)pyrimidin-2-yl)piperidin-4-yl)methoxy)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / platinum(IV) oxide / ethyl acetate; ethanol / 20 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 48 h / 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; HATU; platinum(IV) oxide; In ethanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: 1275992-11-4
methyl 3-((1-(5-(3-methyl-5-phenylbenzofuran-2-carboxamido)pyrimidin-2-yl)piperidin-4-yl)methoxy)benzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.33 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere

2.2: 16 h / 50 °C

3.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / α,α,α-trifluorotoluene / 2 h / 120 °C / Inert atmosphere; Sealed vial; Microwave irradiation

5.1: hydrogen / platinum(IV) oxide / ethyl acetate; ethanol / 20 h / 20 °C / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 48 h / 20 °C

With hydrogenchloride; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; platinum(IV) oxide; In 1,4-dioxane; ethanol; dichloromethane; α,α,α-trifluorotoluene; ethyl acetate; N,N-dimethyl-formamide; mineral oil;