tert-butyl 2-[(3S,4R)-1-benzyl-3-{[1-(2-fluoropentyl)piperidin-4-yl]carbamoyl}-4-methylpyrrolidin-3-yl]acetate

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Chemical Name:tert-butyl 2-[(3S,4R)-1-benzyl-3-{[1-(2-fluoropentyl)piperidin-4-yl]carbamoyl}-4-methylpyrrolidin-3-yl]acetate
CAS No.:1427309-25-8
Molecular Formula:C₂₉H₄₆FN₃O₃
Molecular Weight:503.701
Hs Code.:

Synonyms:tert-butyl 2-[(3S,4R)-1-benzyl-3-{[1-(2-fluoropentyl)piperidin-4-yl]carbamoyl}-4-methylpyrrolidin-3-yl]acetate

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Chemical Property of tert-butyl 2-[(3S,4R)-1-benzyl-3-{[1-(2-fluoropentyl)piperidin-4-yl]carbamoyl}-4-methylpyrrolidin-3-yl]acetate

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Technology Process of tert-butyl 2-[(3S,4R)-1-benzyl-3-{[1-(2-fluoropentyl)piperidin-4-yl]carbamoyl}-4-methylpyrrolidin-3-yl]acetate

There total 22 articles about tert-butyl 2-[(3S,4R)-1-benzyl-3-{[1-(2-fluoropentyl)piperidin-4-yl]carbamoyl}-4-methylpyrrolidin-3-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.5%

: 1427058-44-3
1-(2-fluoropentyl)piperidin-4-amine

: 1427309-24-7
(3S,4R)-1-benzyl-3-[2-(tert-butoxy)-2-oxoethyl]-4-methylpyrrolidine-3-carboxylic acid

: 1427309-25-8
tert-butyl 2-[(3S,4R)-1-benzyl-3-{[1-(2-fluoropentyl)piperidin-4-yl]carbamoyl}-4-methylpyrrolidin-3-yl]acetate

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In water; N,N-dimethyl-formamide; at 20 ℃; for 66h;

Reference yield: 35.5%

: 1427309-24-7
(3S,4R)-1-benzyl-3-[2-(tert-butoxy)-2-oxoethyl]-4-methylpyrrolidine-3-carboxylic acid

: 1-(2-fluoropentyl)piperidin-4-amine

: 1427309-25-8
tert-butyl 2-[(3S,4R)-1-benzyl-3-{[1-(2-fluoropentyl)piperidin-4-yl]carbamoyl}-4-methylpyrrolidin-3-yl]acetate

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 66h;

Reference yield:

: 182223-54-7
piperidin-4-ylcarbamic acid benzyl ester

: 1427309-25-8
tert-butyl 2-[(3S,4R)-1-benzyl-3-{[1-(2-fluoropentyl)piperidin-4-yl]carbamoyl}-4-methylpyrrolidin-3-yl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: (S)-5-benzyl-2,2,3,-trimethylimidazolidin-4-one dichloroacetic acid salt; N-fluorobis(benzenesulfon)imide / tetrahydrofuran / 3.33 h / -10 - 20 °C

1.2: 15.67 h / 20 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C

3.1: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / water; N,N-dimethyl-formamide / 66 h / 20 °C

With (S)-5-benzyl-2,2,3,-trimethylimidazolidin-4-one dichloroacetic acid salt; palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-fluorobis(benzenesulfon)imide; triethylamine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;