2-[(3S,4R)-1-{[2-chloro-6-(trifluoromethyl)phenyl]methyl}-3-{[1-(2-fluoropentyl)piperidin-4-yl]carbamoyl}-4-methylpyrrolidin-3-yl]acetic acid

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Chemical Name:2-[(3S,4R)-1-{[2-chloro-6-(trifluoromethyl)phenyl]methyl}-3-{[1-(2-fluoropentyl)piperidin-4-yl]carbamoyl}-4-methylpyrrolidin-3-yl]acetic acid
CAS No.:1427058-31-8
Molecular Formula:C₂₆H₃₆ClF₄N₃O₃
Molecular Weight:550.037
Hs Code.:

Synonyms:2-[(3S,4R)-1-{[2-chloro-6-(trifluoromethyl)phenyl]methyl}-3-{[1-(2-fluoropentyl)piperidin-4-yl]carbamoyl}-4-methylpyrrolidin-3-yl]acetic acid

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Chemical Property of 2-[(3S,4R)-1-{[2-chloro-6-(trifluoromethyl)phenyl]methyl}-3-{[1-(2-fluoropentyl)piperidin-4-yl]carbamoyl}-4-methylpyrrolidin-3-yl]acetic acid

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Technology Process of 2-[(3S,4R)-1-{[2-chloro-6-(trifluoromethyl)phenyl]methyl}-3-{[1-(2-fluoropentyl)piperidin-4-yl]carbamoyl}-4-methylpyrrolidin-3-yl]acetic acid

There total 25 articles about 2-[(3S,4R)-1-{[2-chloro-6-(trifluoromethyl)phenyl]methyl}-3-{[1-(2-fluoropentyl)piperidin-4-yl]carbamoyl}-4-methylpyrrolidin-3-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1427309-26-9
tert-butyl 2-[(3S,4R)-1-{[2-chloro-6-(trifluoromethyl)phenyl]methyl}-3-{[1-(2-fluoropentyl)piperidin-4-yl]carbamoyl}-4-methylpyrrolidin-3-yl]acetate

: 1427058-31-8
2-[(3S,4R)-1-{[2-chloro-6-(trifluoromethyl)phenyl]methyl}-3-{[1-(2-fluoropentyl)piperidin-4-yl]carbamoyl}-4-methylpyrrolidin-3-yl]acetic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2.58333h;

Reference yield:

: 182223-54-7
piperidin-4-ylcarbamic acid benzyl ester

: 1427058-31-8
2-[(3S,4R)-1-{[2-chloro-6-(trifluoromethyl)phenyl]methyl}-3-{[1-(2-fluoropentyl)piperidin-4-yl]carbamoyl}-4-methylpyrrolidin-3-yl]acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: (S)-5-benzyl-2,2,3,-trimethylimidazolidin-4-one dichloroacetic acid salt; N-fluorobis(benzenesulfon)imide / tetrahydrofuran / 3.33 h / -10 - 20 °C

1.2: 15.67 h / 20 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C

3.1: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / water; N,N-dimethyl-formamide / 66 h / 20 °C

4.1: hydrogen; 20% palladium hydroxide-activated charcoal / methanol / 15 h / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 3.25 h / 45 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 2.58 h / 20 °C

With (S)-5-benzyl-2,2,3,-trimethylimidazolidin-4-one dichloroacetic acid salt; palladium 10% on activated carbon; 20% palladium hydroxide-activated charcoal; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; potassium carbonate; N-fluorobis(benzenesulfon)imide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 220394-97-8
4-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)piperidine

: 1427058-31-8
2-[(3S,4R)-1-{[2-chloro-6-(trifluoromethyl)phenyl]methyl}-3-{[1-(2-fluoropentyl)piperidin-4-yl]carbamoyl}-4-methylpyrrolidin-3-yl]acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride / methanol; water / 23 h / 20 °C

2.1: (S)-5-benzyl-2,2,3,-trimethylimidazolidin-4-one dichloroacetic acid salt; N-fluorobis(benzenesulfon)imide / tetrahydrofuran / 3.33 h / -10 - 20 °C

2.2: 15.67 h / 20 °C

3.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C

4.1: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / water; N,N-dimethyl-formamide / 66 h / 20 °C

5.1: hydrogen; 20% palladium hydroxide-activated charcoal / methanol / 15 h / 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 3.25 h / 45 °C / Inert atmosphere

7.1: trifluoroacetic acid / dichloromethane / 2.58 h / 20 °C

With hydrogenchloride; (S)-5-benzyl-2,2,3,-trimethylimidazolidin-4-one dichloroacetic acid salt; palladium 10% on activated carbon; 20% palladium hydroxide-activated charcoal; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; potassium carbonate; N-fluorobis(benzenesulfon)imide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;