2-(1,2,3,4-Tetrahydroisoquinolin-4-YL)ethanol

Base Information

Chemical Name:2-(1,2,3,4-Tetrahydroisoquinolin-4-YL)ethanol
CAS No.:104465-76-1
Molecular Formula:C₁₁H₁₅NO
Molecular Weight:177.246
Hs Code.:2933499090
DSSTox Substance ID:DTXSID80698207
Mol file:104465-76-1.mol

Synonyms:104465-76-1;2-(1,2,3,4-TETRAHYDROISOQUINOLIN-4-YL)ETHANOL;2-(1,2,3,4-tetrahydroisoquinolin-4-yl)ethan-1-ol;Gefitinib Intermediate;DTXSID80698207;AKOS006285995;FT-0691180

Suppliers and Price of 2-(1,2,3,4-Tetrahydroisoquinolin-4-YL)ethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-(1,2,3,4-TETRAHYDROISOQUINOLIN-4-YL)ETHANOL 98.00%
500G
$ 4908.75

Total 4 raw suppliers

Chemical Property of 2-(1,2,3,4-Tetrahydroisoquinolin-4-YL)ethanol

Chemical Property:

PSA：32.26000
LogP:1.58460
XLogP3:0.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:177.115364102
Heavy Atom Count:13
Complexity:160

Purity/Quality:

97% ^*data from raw suppliers

2-(1,2,3,4-TETRAHYDROISOQUINOLIN-4-YL)ETHANOL 98.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(C2=CC=CC=C2CN1)CCO

Technology Process of 2-(1,2,3,4-Tetrahydroisoquinolin-4-YL)ethanol

There total 10 articles about 2-(1,2,3,4-Tetrahydroisoquinolin-4-YL)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 2-(2-tosyl-1,2,3,4-tetrahydroisoquinolin-4-yl)ethanol

: 104465-76-1
2-(1,2,3,4-tetrahydroisoquinolin-4-yl)ethanol

Guidance literature:: With methanol; magnesium; at 20 ℃; for 5h; Sonication;
DOI:10.1055/s-0037-1610750

Reference yield:

: 23007-65-0
2-benzyl-4-(2-hydroxyethyl)-1,2,3,4-tetrahydroisoquinoline

: 104465-76-1
2-(1,2,3,4-tetrahydroisoquinolin-4-yl)ethanol

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 24h; under 760 Torr;
DOI:10.1021/jo00374a035

Reference yield:

: 21640-31-3
2-(phenylmethyl)isoquinoline-1,3(2H,4H)-dione

: 104465-76-1
2-(1,2,3,4-tetrahydroisoquinolin-4-yl)ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / sodium tert-butoxide / 2-methyl-propan-2-ol / 6 h / Ambient temperature

2: 85 percent / LiAlH₄ / tetrahydrofuran; diisopropyl ether / 24 h

3: concd. hydrochloric acid, H₂ / 20percent Pd/C / methanol / 24 h / 20 °C / 760 Torr

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; sodium t-butanolate; palladium on activated charcoal; In tetrahydrofuran; methanol; di-isopropyl ether; tert-butyl alcohol;
DOI:10.1021/jo00374a035