(+/-)-isocyclocelabenzine

Base Information

Chemical Name:(+/-)-isocyclocelabenzine
CAS No.:104595-98-4
Molecular Formula:C₂₃H₂₇N₃O₂
Molecular Weight:377.486
Hs Code.:

Synonyms:

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Chemical Property of (+/-)-isocyclocelabenzine

Chemical Property:

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Technology Process of (+/-)-isocyclocelabenzine

There total 15 articles about (+/-)-isocyclocelabenzine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23007-65-0
2-benzyl-4-(2-hydroxyethyl)-1,2,3,4-tetrahydroisoquinoline

: 104595-98-4,70503-72-9
(+/-)-isocyclocelabenzine

Guidance literature:: Multi-step reaction with 11 steps

1: concd. hydrochloric acid, H₂ / 20percent Pd/C / methanol / 24 h / 20 °C / 760 Torr

2: 75 percent / sodium acetate / ethanol / 2 h / Heating

3: 90 percent / 2 h / 100 °C

4: 95 percent / KMnO₄, H₂O / acetone / 1 h / Ambient temperature

5: 95 percent / H₂ / platinum oxide / CHCl₃; ethanol / 8 h / 20 °C / 760 Torr

6: 86 percent / 1-methyl-2-chloropyridinium iodide, triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

7: 90 percent / K₂CO₃ / methanol / 2 h / Ambient temperature

8: 75 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

9: 0.5 h / Ambient temperature

10: 5percent aq. NaHCO₃

11: NaBH₄ / methanol / 1 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; potassium permanganate; 2-chloro-1-methyl-pyridinium iodide; water; hydrogen; sodium acetate; sodium hydrogencarbonate; potassium carbonate; triethylamine; pyridinium chlorochromate; platinum(IV) oxide; palladium on activated charcoal; In methanol; ethanol; dichloromethane; chloroform; acetone;
DOI:10.1021/jo00374a035

Reference yield:

: 104465-76-1
2-(1,2,3,4-tetrahydroisoquinolin-4-yl)ethanol

: 104595-98-4,70503-72-9
(+/-)-isocyclocelabenzine

Guidance literature:: Multi-step reaction with 10 steps

1: 75 percent / sodium acetate / ethanol / 2 h / Heating

2: 90 percent / 2 h / 100 °C

3: 95 percent / KMnO₄, H₂O / acetone / 1 h / Ambient temperature

4: 95 percent / H₂ / platinum oxide / CHCl₃; ethanol / 8 h / 20 °C / 760 Torr

5: 86 percent / 1-methyl-2-chloropyridinium iodide, triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

6: 90 percent / K₂CO₃ / methanol / 2 h / Ambient temperature

7: 75 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

8: 0.5 h / Ambient temperature

9: 5percent aq. NaHCO₃

10: NaBH₄ / methanol / 1 h / Ambient temperature

With sodium tetrahydroborate; potassium permanganate; 2-chloro-1-methyl-pyridinium iodide; water; hydrogen; sodium acetate; sodium hydrogencarbonate; potassium carbonate; triethylamine; pyridinium chlorochromate; platinum(IV) oxide; In methanol; ethanol; dichloromethane; chloroform; acetone;
DOI:10.1021/jo00374a035

Reference yield:

: 21640-31-3
2-(phenylmethyl)isoquinoline-1,3(2H,4H)-dione

: 104595-98-4,70503-72-9
(+/-)-isocyclocelabenzine

Guidance literature:: Multi-step reaction with 13 steps

1: 70 percent / sodium tert-butoxide / 2-methyl-propan-2-ol / 6 h / Ambient temperature

2: 85 percent / LiAlH₄ / tetrahydrofuran; diisopropyl ether / 24 h

3: concd. hydrochloric acid, H₂ / 20percent Pd/C / methanol / 24 h / 20 °C / 760 Torr

4: 75 percent / sodium acetate / ethanol / 2 h / Heating

5: 90 percent / 2 h / 100 °C

6: 95 percent / KMnO₄, H₂O / acetone / 1 h / Ambient temperature

7: 95 percent / H₂ / platinum oxide / CHCl₃; ethanol / 8 h / 20 °C / 760 Torr

8: 86 percent / 1-methyl-2-chloropyridinium iodide, triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

9: 90 percent / K₂CO₃ / methanol / 2 h / Ambient temperature

10: 75 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

11: 0.5 h / Ambient temperature

12: 5percent aq. NaHCO₃

13: NaBH₄ / methanol / 1 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; potassium permanganate; lithium aluminium tetrahydride; 2-chloro-1-methyl-pyridinium iodide; water; hydrogen; sodium acetate; sodium hydrogencarbonate; potassium carbonate; triethylamine; pyridinium chlorochromate; sodium t-butanolate; platinum(IV) oxide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; di-isopropyl ether; acetone; tert-butyl alcohol;
DOI:10.1021/jo00374a035