(E)-N-{4-[3-methyl-2-oxo-3-(phenylselanyl)-1-pyrrolidinyl]butyl}-3-phenyl-2-propenamide

Base Information

Chemical Name:(E)-N-{4-[3-methyl-2-oxo-3-(phenylselanyl)-1-pyrrolidinyl]butyl}-3-phenyl-2-propenamide
CAS No.:462629-68-1
Molecular Formula:C₂₄H₂₈N₂O₂Se
Molecular Weight:455.459
Hs Code.:

Synonyms:(E)-N-{4-[3-methyl-2-oxo-3-(phenylselanyl)-1-pyrrolidinyl]butyl}-3-phenyl-2-propenamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-N-{4-[3-methyl-2-oxo-3-(phenylselanyl)-1-pyrrolidinyl]butyl}-3-phenyl-2-propenamide

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Technology Process of (E)-N-{4-[3-methyl-2-oxo-3-(phenylselanyl)-1-pyrrolidinyl]butyl}-3-phenyl-2-propenamide

There total 6 articles about (E)-N-{4-[3-methyl-2-oxo-3-(phenylselanyl)-1-pyrrolidinyl]butyl}-3-phenyl-2-propenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 102-92-1,17082-09-6
Cinnamoyl chloride

: 462629-67-0
1-(4-aminobutyl)-3-methyl-3-(phenylselanyl)-2-pyrrolidinone

: 462629-68-1
(E)-N-{4-[3-methyl-2-oxo-3-(phenylselanyl)-1-pyrrolidinyl]butyl}-3-phenyl-2-propenamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 0.25h;
DOI:10.1016/S0040-4039(02)00869-9

Reference yield:

: 2555-05-7
3-methyl-2-pyrrolidinone

: 462629-68-1
(E)-N-{4-[3-methyl-2-oxo-3-(phenylselanyl)-1-pyrrolidinyl]butyl}-3-phenyl-2-propenamide

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / NEt₃; DMAP / acetonitrile / 10 h / 20 °C

2: 89 percent / KHMDS / diethyl ether / 0.5 h / -65 °C

3: 83 percent / CF₃COOH / toluene / 1 h / 20 °C

4: 60 percent / KHMDS / dimethylformamide / 10 h / 0 - 20 °C

5: 90 percent / NH₂-NH₂ / ethanol / 2 h / Heating

6: 95 percent / NEt₃ / CH₂Cl₂ / 0.25 h / 20 °C

With dmap; potassium hexamethylsilazane; triethylamine; trifluoroacetic acid; hydrazine; In diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/S0040-4039(02)00869-9

Reference yield:

: 171017-18-8
tert-butyl 3-methyl-2-oxo-1-pyrrolidine-carboxylate

: 462629-68-1
(E)-N-{4-[3-methyl-2-oxo-3-(phenylselanyl)-1-pyrrolidinyl]butyl}-3-phenyl-2-propenamide

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / KHMDS / diethyl ether / 0.5 h / -65 °C

2: 83 percent / CF₃COOH / toluene / 1 h / 20 °C

3: 60 percent / KHMDS / dimethylformamide / 10 h / 0 - 20 °C

4: 90 percent / NH₂-NH₂ / ethanol / 2 h / Heating

5: 95 percent / NEt₃ / CH₂Cl₂ / 0.25 h / 20 °C

With potassium hexamethylsilazane; triethylamine; trifluoroacetic acid; hydrazine; In diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(02)00869-9