2555-05-7Relevant articles and documents
Ring-Expansion Reactions Catalyzed by Hydrophobic Vitamin B12 in Synthetic Bilayer Membrane
Murakami, Yukito,Hisaeda, Yoshio,Ohno, Teruhisa,Matsuda, Yoshihisa
, p. 621 - 624 (1988)
Heptapropyl cobyrinate perchlorate catalyzed the ring-expansion reactions, which convert 2-methyl-1,3-cyclopentanedion and 3-methyl-2-pyrrolidinone into 1,4-cyclohexanedione and 2-piperidinone, respectively, in single-compartment bilayer vesicles.
N-(AZAARYL)CYCLOLACTAM-1-CARBOXAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF
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Paragraph 0143; 0289; 0290, (2020/03/23)
An N-(azaaryl)cyclolactam-1-carboxamide derivative having a structure of formula (I), a preparation method therefor, and a use thereof are disclosed in the application. Each substituent are defined in the specification and claims. The series of compounds of the application can be widely applied in the preparation of drugs for treating cancer, tumor, autoimmune disease, metabolic disease or metastatic disease, particularly for treating ovarian cancer, pancreatic cancer, prostate cancer, breast cancer, cervical cancer, glioblastoma, multiple myeloma, metabolic disease, neurodegenerative disease, primary tumor site metastasis or osseous metastasis cancer, and are expected to be developed into a new generation of CSF-1R inhibitor drugs.
Carbazole-containing amides and ureas: Discovery of cryptochrome modulators as antihyperglycemic agents
Humphries, Paul S.,Bersot, Ross,Kincaid, John,Mabery, Eric,McCluskie, Kerryn,Park, Timothy,Renner, Travis,Riegler, Erin,Steinfeld, Tod,Turtle, Eric D.,Wei, Zhi-Liang,Willis, Erik
supporting information, p. 293 - 297 (2018/01/04)
A series of novel carbazole-containing amides and ureas were synthesized. A structure–activity relationship study of these compounds led to the identification of potent cryptochrome modulators. Based on the desired pharmacokinetic/pharmacodynamic parameters and the results of efficacy studies in db/db mice, compound 50 was selected for further profiling.
