1-[6-(benzyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-2-yl]-3-(2-hydroxyethyl)urea

Base Information

Chemical Name:1-[6-(benzyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-2-yl]-3-(2-hydroxyethyl)urea
CAS No.:1452129-13-3
Molecular Formula:C₂₀H₂₄N₆O₄
Molecular Weight:412.448
Hs Code.:

Synonyms:1-[6-(benzyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-2-yl]-3-(2-hydroxyethyl)urea

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Chemical Property of 1-[6-(benzyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-2-yl]-3-(2-hydroxyethyl)urea

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Technology Process of 1-[6-(benzyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-2-yl]-3-(2-hydroxyethyl)urea

There total 6 articles about 1-[6-(benzyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-2-yl]-3-(2-hydroxyethyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₁₇N₅O₃

: 141-43-5
ethanolamine

: 1452129-13-3
1-[6-(benzyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-2-yl]-3-(2-hydroxyethyl)urea

Guidance literature:: In tetrahydrofuran; at 0 - 20 ℃; chemoselective reaction; Inert atmosphere;
DOI:10.1055/s-0033-1338482

Reference yield:

: 1452129-04-2
6-(benzyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-2-amine

: 1452129-13-3
1-[6-(benzyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-2-yl]-3-(2-hydroxyethyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: bis(trichloromethyl) carbonate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

2: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With bis(trichloromethyl) carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1055/s-0033-1338482

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 1452129-13-3
1-[6-(benzyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-2-yl]-3-(2-hydroxyethyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran / 20 °C / Inert atmosphere

2: bis(trichloromethyl) carbonate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

3: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With bis(trichloromethyl) carbonate; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1055/s-0033-1338482