[5-(3-methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin-1-yl]acetic acid ethyl ester

Base Information

• Chemical Name: [5-(3-methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin-1-yl]acetic acid ethyl ester
• CAS No.: 1184304-25-3
• Molecular Formula: C₁₇H₂₀N₂O₄
• Molecular Weight: 316.357

Synonyms:[5-(3-methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin-1-yl]acetic acid ethyl ester

Chemical Property of [5-(3-methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin-1-yl]acetic acid ethyl ester

Chemical Property:

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Technology Process of [5-(3-methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin-1-yl]acetic acid ethyl ester

There total 3 articles about [5-(3-methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin-1-yl]acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-(3-methoxybenzyl)-6-methylpyridazin-3(2H)-one (1184304-24-2) + ethyl bromoacetate (105-36-2) → [5-(3-methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin-1-yl]acetic acid ethyl ester (1184304-25-3)

Guidance literature:

With potassium carbonate; In acetonitrile; for 6h; Reflux;

DOI:10.1021/jm900592h

Reference yield:

3-methoxy-benzaldehyde (591-31-1) → [5-(3-methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin-1-yl]acetic acid ethyl ester (1184304-25-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / Reflux

2: potassium carbonate / acetonitrile / Reflux

With potassium carbonate; potassium hydroxide; In ethanol; acetonitrile; 1: |Knoevenagel Condensation;

DOI:10.1002/ddr.21076

Reference yield:

3-methyl-4,5-dihydro-6-oxopyridazine (5157-08-4) → [5-(3-methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin-1-yl]acetic acid ethyl ester (1184304-25-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / Reflux

2: potassium carbonate / acetonitrile / Reflux

With potassium carbonate; potassium hydroxide; In ethanol; acetonitrile; 1: |Knoevenagel Condensation;

DOI:10.1002/ddr.21076

upstream raw materials:

4-(3-methoxybenzyl)-6-methylpyridazin-3(2H)-one

ethyl bromoacetate

3-methyl-4,5-dihydro-6-oxopyridazine

3-methoxy-benzaldehyde

Downstream raw materials:

[5-(3-methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin-1-yl]acetic acid

2-(2-hydroxyethyl)-4-(3-methoxybenzyl)-6-methyl-pyridazin-3(2H)-one

N-(4-bromophenyl)-2-[5-(3-methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin-1-yl]-acetamide

2-[5-(3-methoxybenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl]-N-[4-(methylthio)phenyl]acetamide

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