5'-O-DMTr-2'-O-TBDMS-uridine-3'-O-(2-chlorophenyl)phosphate triethylammonium salt

Base Information

• Chemical Name: 5'-O-DMTr-2'-O-TBDMS-uridine-3'-O-(2-chlorophenyl)phosphate triethylammonium salt
• CAS No.: 127553-47-3
• Molecular Formula: C₆H₁₅N*C₄₂H₄₈ClN₂O₁₁PSi
• Molecular Weight: 952.554

Synonyms:5'-O-DMTr-2'-O-TBDMS-uridine-3'-O-(2-chlorophenyl)phosphate triethylammonium salt

Chemical Property of 5'-O-DMTr-2'-O-TBDMS-uridine-3'-O-(2-chlorophenyl)phosphate triethylammonium salt

Chemical Property:

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Technology Process of 5'-O-DMTr-2'-O-TBDMS-uridine-3'-O-(2-chlorophenyl)phosphate triethylammonium salt

There total 4 articles about 5'-O-DMTr-2'-O-TBDMS-uridine-3'-O-(2-chlorophenyl)phosphate triethylammonium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl uridine (81246-80-2) + triethylamine carbonate (15715-58-9) + 2-chlorophenyl dichlorophosphate (15074-54-1) → 5'-O-DMTr-2'-O-TBDMS-uridine-3'-O-(2-chlorophenyl)phosphate triethylammonium salt (127553-47-3)

Guidance literature:

2-chlorophenyl dichlorophosphate; With 1,2,3-triazole; triethylamine; In 1,4-dioxane; at 5 ℃; for 1h;

5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl uridine; With 1-methyl-1H-imidazole; In pyridine; at -5 ℃; for 1h;

triethylamine carbonate; In pyridine;

Reference yield:

5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl uridine (81246-80-2) + triethylamine carbonate (15715-58-9) + triethylamine (121-44-8) + 2-chlorophenyl dichlorophosphate (15074-54-1) → 5'-O-DMTr-2'-O-TBDMS-uridine-3'-O-(2-chlorophenyl)phosphate triethylammonium salt (127553-47-3)

Guidance literature:

5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl uridine; triethylamine; 2-chlorophenyl dichlorophosphate; With 1,2,4-Triazole; In dichloromethane;

triethylamine carbonate;

DOI:10.1007/s11426-019-9662-5

Reference yield:

5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl uridine (81246-80-2) + triethylamine (121-44-8) + 2-chlorophenyl dichlorophosphate (15074-54-1) → 5'-O-DMTr-2'-O-TBDMS-uridine-3'-O-(2-chlorophenyl)phosphate triethylammonium salt (127553-47-3)

Guidance literature:

With pyridine; Yield given. Multistep reaction; 1) H₂O, 2) CH₂Cl₂;

DOI:10.1016/S0040-4020(01)80945-5

upstream raw materials:

5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl uridine

triethylamine

2-chlorophenyl dichlorophosphate

triethylamine carbonate

Downstream raw materials:

C₆₅H₆₆ClN₄O₁₈PSi

C₄₄H₄₈ClN₄O₁₆PSi

uridylyl-3',5'-uridine

5'-O-dimethoxytrityl-2'-O-t-butyldimethylsilyluridine-3'-O-chlorophenylphosphate-5'-O-2'-O-t-butyldimethylsilyluridine

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