2-(benzyloxy)-6-(2-(3,4-dimethoxyphenethylamino)-2-oxoethyl)-3-methoxybenzyl acetate

Base Information

• Chemical Name: 2-(benzyloxy)-6-(2-(3,4-dimethoxyphenethylamino)-2-oxoethyl)-3-methoxybenzyl acetate
• CAS No.: 1429118-52-4
• Molecular Formula: C₂₉H₃₃NO₇
• Molecular Weight: 507.584
• Mol file: 1429118-52-4.mol

Synonyms:2-(benzyloxy)-6-(2-(3,4-dimethoxyphenethylamino)-2-oxoethyl)-3-methoxybenzyl acetate

Chemical Property of 2-(benzyloxy)-6-(2-(3,4-dimethoxyphenethylamino)-2-oxoethyl)-3-methoxybenzyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(benzyloxy)-6-(2-(3,4-dimethoxyphenethylamino)-2-oxoethyl)-3-methoxybenzyl acetate

There total 13 articles about 2-(benzyloxy)-6-(2-(3,4-dimethoxyphenethylamino)-2-oxoethyl)-3-methoxybenzyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-<2-(3-Benzyloxy-4-methoxyphenyl)-ethyl>-(3,4-dimethoxy-2-hydroxymethyl)-phenylacetamide (91421-51-1) + acetyl chloride (75-36-5) → 2-(benzyloxy)-6-(2-(3,4-dimethoxyphenethylamino)-2-oxoethyl)-3-methoxybenzyl acetate (1429118-52-4)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 1.5h;

DOI:10.1016/j.bmc.2012.12.016

Reference yield: 67.0%

acetic anhydride (108-24-7) + N-<2-(3-Benzyloxy-4-methoxyphenyl)-ethyl>-(3,4-dimethoxy-2-hydroxymethyl)-phenylacetamide (91421-51-1) → 2-(benzyloxy)-6-(2-(3,4-dimethoxyphenethylamino)-2-oxoethyl)-3-methoxybenzyl acetate (1429118-52-4)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2017.01.090

Reference yield:

3-benzyloxy-4-methoxyphenylethylamine (36455-21-7) → 2-(benzyloxy)-6-(2-(3,4-dimethoxyphenethylamino)-2-oxoethyl)-3-methoxybenzyl acetate (1429118-52-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 14 h / Reflux

2: pyridine / dichloromethane / 1.5 h / 0 - 20 °C

With pyridine; In ethanol; dichloromethane;

DOI:10.1016/j.bmc.2012.12.016

upstream raw materials:

3-benzyloxy-4-methoxy-β-nitrostyrene

3-benzyloxy-4-methoxyphenylethylamine

Methyl 4-hydroxyphenylacetate

methyl 3-bromo-4-hydroxyphenylacetate

Downstream raw materials:

14-(S)-3,9-dibenzyloxy-2,10-dimethoxytetrahydroprotoberberine

14-(R)-3,9-dibenzyloxy-2,10-dimethoxytetrahydroprotoberberine

corypalmine

(+)-corypalmine