1,1-Dimethylethyl 7-[(3S)-2-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)-1-pyrrolidinyl]-1,3,4,5-tetrahydro-2H-2-benzazepine-2-carboxylate

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Chemical Name:1,1-Dimethylethyl 7-[(3S)-2-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)-1-pyrrolidinyl]-1,3,4,5-tetrahydro-2H-2-benzazepine-2-carboxylate
CAS No.:939043-34-2
Molecular Formula:C₂₇H₃₃N₃O₅
Molecular Weight:479.576
Hs Code.:

Synonyms:1,1-Dimethylethyl 7-[(3S)-2-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)-1-pyrrolidinyl]-1,3,4,5-tetrahydro-2H-2-benzazepine-2-carboxylate

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Chemical Property of 1,1-Dimethylethyl 7-[(3S)-2-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)-1-pyrrolidinyl]-1,3,4,5-tetrahydro-2H-2-benzazepine-2-carboxylate

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Technology Process of 1,1-Dimethylethyl 7-[(3S)-2-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)-1-pyrrolidinyl]-1,3,4,5-tetrahydro-2H-2-benzazepine-2-carboxylate

There total 6 articles about 1,1-Dimethylethyl 7-[(3S)-2-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)-1-pyrrolidinyl]-1,3,4,5-tetrahydro-2H-2-benzazepine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 939043-33-1
[(3S)-4-[(2-{[(1,1-Dimethylethyl)oxy]carbonyl}-2,3,4,5-tetrahydro-1H-2-benzazepin-7-yl)amino]-4-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)butyl](dimethyl)sulfonium iodide

: 939043-34-2
1,1-Dimethylethyl 7-[(3S)-2-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)-1-pyrrolidinyl]-1,3,4,5-tetrahydro-2H-2-benzazepine-2-carboxylate

Guidance literature:: With caesium carbonate; In acetonitrile; at 20 - 60 ℃; for 1.16667h;

Reference yield:

: 939043-32-0
1,1-Dimethylethyl 7-[(N-{[(phenylmethyl)oxy]carbonyl}-L-methionyl)amino]-1,3,4,5-tetrahydro-2H-2-benzazepine-2-carboxylate

: 939043-34-2
1,1-Dimethylethyl 7-[(3S)-2-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)-1-pyrrolidinyl]-1,3,4,5-tetrahydro-2H-2-benzazepine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: methyl iodide / acetonitrile / 20 °C

2: caesium carbonate / acetonitrile / 60 °C

With caesium carbonate; methyl iodide; In acetonitrile;
DOI:10.1016/j.bmcl.2011.01.129

Reference yield:

: 939043-31-9
tert-butyl 7-amino-1,3,4,5-tetrahydro-2H-benzo[c]azepine-2-carboxylate

: 939043-34-2
1,1-Dimethylethyl 7-[(3S)-2-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)-1-pyrrolidinyl]-1,3,4,5-tetrahydro-2H-2-benzazepine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 20 °C

2: methyl iodide / acetonitrile / 20 °C

3: caesium carbonate / acetonitrile / 60 °C

With caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; methyl iodide; In dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2011.01.129