[(3S)-4-[(2-{[(1,1-Dimethylethyl)oxy]carbonyl}-2,3,4,5-tetrahydro-1H-2-benzazepin-7-yl)amino]-4-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)butyl](dimethyl)sulfonium iodide

Base Information

Chemical Name:[(3S)-4-[(2-{[(1,1-Dimethylethyl)oxy]carbonyl}-2,3,4,5-tetrahydro-1H-2-benzazepin-7-yl)amino]-4-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)butyl](dimethyl)sulfonium iodide
CAS No.:939043-33-1
Molecular Formula:C₂₉H₄₀N₃O₅S*I
Molecular Weight:669.624
Hs Code.:

[(3S)-4-[(2-{[(1,1-Dimethylethyl)oxy]carbonyl}-2,3,4,5-tetrahydro-1H-2-benzazepin-7-yl)amino]-4-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)butyl](dimethyl)sulfonium iodide

Synonyms:[(3S)-4-[(2-{[(1,1-Dimethylethyl)oxy]carbonyl}-2,3,4,5-tetrahydro-1H-2-benzazepin-7-yl)amino]-4-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)butyl](dimethyl)sulfonium iodide

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Chemical Property of [(3S)-4-[(2-{[(1,1-Dimethylethyl)oxy]carbonyl}-2,3,4,5-tetrahydro-1H-2-benzazepin-7-yl)amino]-4-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)butyl](dimethyl)sulfonium iodide

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Technology Process of [(3S)-4-[(2-{[(1,1-Dimethylethyl)oxy]carbonyl}-2,3,4,5-tetrahydro-1H-2-benzazepin-7-yl)amino]-4-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)butyl](dimethyl)sulfonium iodide

There total 6 articles about [(3S)-4-[(2-{[(1,1-Dimethylethyl)oxy]carbonyl}-2,3,4,5-tetrahydro-1H-2-benzazepin-7-yl)amino]-4-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)butyl](dimethyl)sulfonium iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 939043-32-0
1,1-Dimethylethyl 7-[(N-{[(phenylmethyl)oxy]carbonyl}-L-methionyl)amino]-1,3,4,5-tetrahydro-2H-2-benzazepine-2-carboxylate

: 74-88-4
methyl iodide

: 939043-33-1
[(3S)-4-[(2-{[(1,1-Dimethylethyl)oxy]carbonyl}-2,3,4,5-tetrahydro-1H-2-benzazepin-7-yl)amino]-4-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)butyl](dimethyl)sulfonium iodide

Guidance literature:: In acetonitrile; at 20 ℃;

Reference yield:

: 939043-32-0
1,1-Dimethylethyl 7-[(N-{[(phenylmethyl)oxy]carbonyl}-L-methionyl)amino]-1,3,4,5-tetrahydro-2H-2-benzazepine-2-carboxylate

: 939043-33-1
[(3S)-4-[(2-{[(1,1-Dimethylethyl)oxy]carbonyl}-2,3,4,5-tetrahydro-1H-2-benzazepin-7-yl)amino]-4-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)butyl](dimethyl)sulfonium iodide

Guidance literature:: With methyl iodide; In acetonitrile; at 20 ℃;
DOI:10.1016/j.bmcl.2011.01.129

Reference yield:

: 939043-31-9
tert-butyl 7-amino-1,3,4,5-tetrahydro-2H-benzo[c]azepine-2-carboxylate

: 939043-33-1
[(3S)-4-[(2-{[(1,1-Dimethylethyl)oxy]carbonyl}-2,3,4,5-tetrahydro-1H-2-benzazepin-7-yl)amino]-4-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)butyl](dimethyl)sulfonium iodide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 20 °C

2: methyl iodide / acetonitrile / 20 °C

With N-ethyl-N,N-diisopropylamine; HATU; methyl iodide; In dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2011.01.129