(2,2-dimethyl-cyclopropyl)-[4-(3-methoxy-phenyl)-piperidin-1-yl]-methanone

Base Information

Chemical Name:(2,2-dimethyl-cyclopropyl)-[4-(3-methoxy-phenyl)-piperidin-1-yl]-methanone
CAS No.:1276045-05-6
Molecular Formula:C₁₈H₂₅NO₂
Molecular Weight:287.402
Hs Code.:

Synonyms:(2,2-dimethyl-cyclopropyl)-[4-(3-methoxy-phenyl)-piperidin-1-yl]-methanone

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Chemical Property of (2,2-dimethyl-cyclopropyl)-[4-(3-methoxy-phenyl)-piperidin-1-yl]-methanone

Chemical Property:

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Technology Process of (2,2-dimethyl-cyclopropyl)-[4-(3-methoxy-phenyl)-piperidin-1-yl]-methanone

There total 5 articles about (2,2-dimethyl-cyclopropyl)-[4-(3-methoxy-phenyl)-piperidin-1-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1307314-95-9
4-(3-methoxy-phenyl)-piperidine trifluoroacetate

: 50675-57-5,89312-77-6,103554-20-7
dl-2,2-dimethylcyclopropane-1-carboxylic acid chloride

: 1276045-05-6
(2,2-dimethyl-cyclopropyl)-[4-(3-methoxy-phenyl)-piperidin-1-yl]-methanone

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2010.12.068

Reference yield:

: 1276045-26-1
4-(3-methoxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

: 1276045-05-6
(2,2-dimethyl-cyclopropyl)-[4-(3-methoxy-phenyl)-piperidin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 1 h / 20 °C

2: triethylamine / dichloromethane / 0 - 20 °C

With triethylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2010.12.068

Reference yield:

: 766-85-8
3-methoxy-1-iodobenzene

: 1276045-05-6
(2,2-dimethyl-cyclopropyl)-[4-(3-methoxy-phenyl)-piperidin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 4 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / N,N-dimethyl-formamide / 20 - 80 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 20 °C / 10343.2 Torr

3: dichloromethane / 1 h / 20 °C

4: triethylamine / dichloromethane / 0 - 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2010.12.068