2-Methyl-3-phenyl-2H-azirine-2-carboxylic acid dibenzylamide

Base Information

• Chemical Name: 2-Methyl-3-phenyl-2H-azirine-2-carboxylic acid dibenzylamide
• CAS No.: 122689-97-8
• Molecular Formula: C₂₄H₂₂N₂O
• Molecular Weight: 354.451
• Mol file: 122689-97-8.mol

Synonyms:2-Methyl-3-phenyl-2H-azirine-2-carboxylic acid dibenzylamide

Chemical Property of 2-Methyl-3-phenyl-2H-azirine-2-carboxylic acid dibenzylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2-Methyl-3-phenyl-2H-azirine-2-carboxylic acid dibenzylamide

There total 3 articles about 2-Methyl-3-phenyl-2H-azirine-2-carboxylic acid dibenzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

Dibenzyl-(4-methyl-3-phenyl-isoxazol-5-yl)-amine (122689-89-8) → 2-Methyl-3-phenyl-2H-azirine-2-carboxylic acid dibenzylamide (122689-97-8)

Guidance literature:

In neat (no solvent); at 230 ℃; for 0.2h;

DOI:10.1016/S0040-4039(00)82266-2

Reference yield:

5-amino-4-methyl-3-phenylisoxazole (4320-84-7) → 2-Methyl-3-phenyl-2H-azirine-2-carboxylic acid dibenzylamide (122689-97-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.)NaH / 1.) DMF, 2.) 0 deg C to room temp.

2: 69 percent / neat (no solvent) / 0.2 h / 230 °C

With sodium hydride; In neat (no solvent);

DOI:10.1016/S0040-4039(00)82266-2

Reference yield:

benzyl bromide (100-39-0) → 2-Methyl-3-phenyl-2H-azirine-2-carboxylic acid dibenzylamide (122689-97-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.)NaH / 1.) DMF, 2.) 0 deg C to room temp.

2: 69 percent / neat (no solvent) / 0.2 h / 230 °C

With sodium hydride; In neat (no solvent);

DOI:10.1016/S0040-4039(00)82266-2

upstream raw materials:

Dibenzyl-(4-methyl-3-phenyl-isoxazol-5-yl)-amine

5-amino-4-methyl-3-phenylisoxazole

benzyl bromide

Downstream raw materials:

N-benzoyl-alanine dibenzylamide