6-butoxy-4-(3-cyclopentyl-5-(hydroxymethyl)phenylamino)-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-carboxamide

Base Information

Chemical Name:6-butoxy-4-(3-cyclopentyl-5-(hydroxymethyl)phenylamino)-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-carboxamide
CAS No.:1445787-31-4
Molecular Formula:C₃₂H₃₇N₅O₅
Molecular Weight:571.676
Hs Code.:

Synonyms:6-butoxy-4-(3-cyclopentyl-5-(hydroxymethyl)phenylamino)-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-carboxamide

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Chemical Property of 6-butoxy-4-(3-cyclopentyl-5-(hydroxymethyl)phenylamino)-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-carboxamide

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Technology Process of 6-butoxy-4-(3-cyclopentyl-5-(hydroxymethyl)phenylamino)-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-carboxamide

There total 7 articles about 6-butoxy-4-(3-cyclopentyl-5-(hydroxymethyl)phenylamino)-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1445790-52-2
6-butoxy-7-chloro-4-(3-cyclopentyl-5-(hydroxymethyl)phenylamino)quinoline-3-carboxamide

: 89641-18-9
2,4-dimethoxypyrimidin-5-ylboronic acid

: 1445787-31-4
6-butoxy-4-(3-cyclopentyl-5-(hydroxymethyl)phenylamino)-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-carboxamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 100 ℃; for 20h; Inert atmosphere;

Reference yield:

: 1445790-46-4
methyl 3-amino-5-cyclopentylbenzoate

: 1445787-31-4
6-butoxy-4-(3-cyclopentyl-5-(hydroxymethyl)phenylamino)-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C

2: ethanol / 3 h / Reflux

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 20 h / 100 °C / Inert atmosphere

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; ethanol; water;

Reference yield:

: 6307-87-5
methyl 3-bromo-5-nitrobenzoate

: 1445787-31-4
6-butoxy-4-(3-cyclopentyl-5-(hydroxymethyl)phenylamino)-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

2: hydrogen; acetic acid; palladium 10% on activated carbon / methanol / 12 h / 50 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C

4: ethanol / 3 h / Reflux

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 20 h / 100 °C / Inert atmosphere

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;