Thieno[3,2-b]pyridin-7-amine

Base Information

• Chemical Name: Thieno[3,2-b]pyridin-7-amine
• CAS No.: 104273-32-7
• Molecular Formula: C₇H₆N₂S
• Molecular Weight: 150.204
• Hs Code.: 2934999090
• European Community (EC) Number: 888-683-9
• DSSTox Substance ID: DTXSID30543697
• Nikkaji Number: J2.050.465J
• Wikidata: Q82420639
• Mol file: 104273-32-7.mol

Synonyms:Thieno[3,2-b]pyridin-7-amine;104273-32-7;Thieno[3,2-b]pyridin-7-amine (9CI);SCHEMBL4037241;DTXSID30543697;MFCD09056748;AKOS006332305;MB06918;AS-50608;CS-0054402;P10698;EN300-2983320

Chemical Property of Thieno[3,2-b]pyridin-7-amine

Chemical Property:

• PSA: 67.15000
• LogP: 2.45970
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 150.02516937
• Heavy Atom Count: 10
• Complexity: 129

Purity/Quality:

97% ^*data from raw suppliers

Thieno[3,2-b]pyridin-7-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C2C=CSC2=C1N

Technology Process of Thieno[3,2-b]pyridin-7-amine

There total 5 articles about Thieno[3,2-b]pyridin-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

7-azido-thieno[3.2-b]pyridine → 7-aminothieno<3,2-b>pyridine hydrate (104273-32-7)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; for 24h;

DOI:10.1016/j.tetlet.2004.04.032

Reference yield: 56.0%

7-nitrothieno<3,2-b>pyridine 4-oxide (104273-28-1) → 7-aminothieno<3,2-b>pyridine hydrate (104273-32-7)

Guidance literature:

With iron; In acetic acid; at 100 ℃; for 1h;

Reference yield:

thieno[3,2-b]pyridin-7(4H)-one (69627-02-7) → 7-aminothieno<3,2-b>pyridine hydrate (104273-32-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / diphenylphosphoryl azide; triethylamine / dimethylformamide / 24 h / 100 °C

2: 88 percent / hydrogen; Pd/C / methanol / 24 h

With palladium on activated charcoal; diphenylphosphoranyl azide; hydrogen; triethylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2004.04.032

upstream raw materials:

7-nitrothieno<3,2-b>pyridine 4-oxide

thieno[3,2-b]pyridin-7(4H)-one

thieno<3,2-b>pyridine 4-oxide monohydrate

thieno[3,2-b]pyridine

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