(7aR,10R,12S)-10-(1H-benzotriazol-1-yl)-7a,8,9,10-tetrahydro-12-phenyl-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazine

Base Information

• Chemical Name: (7aR,10R,12S)-10-(1H-benzotriazol-1-yl)-7a,8,9,10-tetrahydro-12-phenyl-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazine
• CAS No.: 667870-41-9
• Molecular Formula: C₂₇H₂₂N₄O
• Molecular Weight: 418.498

Synonyms:(7aR,10R,12S)-10-(1H-benzotriazol-1-yl)-7a,8,9,10-tetrahydro-12-phenyl-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazine

Chemical Property of (7aR,10R,12S)-10-(1H-benzotriazol-1-yl)-7a,8,9,10-tetrahydro-12-phenyl-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (7aR,10R,12S)-10-(1H-benzotriazol-1-yl)-7a,8,9,10-tetrahydro-12-phenyl-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazine

There total 1 articles about (7aR,10R,12S)-10-(1H-benzotriazol-1-yl)-7a,8,9,10-tetrahydro-12-phenyl-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1,2,3-Benzotriazole (95-14-7,27556-51-0) + butanedial (638-37-9) + (S)-l-(α-aminobenzyl)-2-naphthol (R,R)-tartrate (219897-70-8,219897-36-6) → (7aR,10R,12S)-10-(1H-benzotriazol-1-yl)-7a,8,9,10-tetrahydro-12-phenyl-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazine (667870-41-9)

Guidance literature:

In dichloromethane; at -5 - 0 ℃; for 5h;

DOI:10.1055/s-2003-43353

Reference yield: 96.0%

(7aR,10R,12S)-10-(1H-benzotriazol-1-yl)-7a,8,9,10-tetrahydro-12-phenyl-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazine (667870-41-9) + allylmagnesium bromide (1730-25-2) → C27H29NO (1042368-73-9)

Guidance literature:

(7aR,10R,12S)-10-(1H-benzotriazol-1-yl)-7a,8,9,10-tetrahydro-12-phenyl-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazine; allylmagnesium bromide; In diethyl ether; toluene; at -78 ℃; for 0.166667h;

With water; ammonium chloride; In diethyl ether; toluene; at 0 ℃;

DOI:10.1021/jo200069m

Reference yield: 92.0%

ethynylmagnesium chloride (65032-27-1) + (7aR,10R,12S)-10-(1H-benzotriazol-1-yl)-7a,8,9,10-tetrahydro-12-phenyl-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazine (667870-41-9) → (7aR,10R,12S)-7a,8,9,10-tetrahydro-10-ethynyl-12-phenyl-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazine (1283098-16-7)

Guidance literature:

In tetrahydrofuran; at -40 - 0 ℃; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/jo200069m

upstream raw materials:

1,2,3-Benzotriazole

butanedial

(S)-l-(α-aminobenzyl)-2-naphthol (R,R)-tartrate

Downstream raw materials:

(7aR,12S)-12-phenyl-7a,8,9,10-tetrahydro-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazine

(S)-1-(phenyl(pyrrolidin-1-yl)methyl)naphthalen-2-ol

(7aR,10R,12S)-7a,8,9,10-tetrahydro-10-ethynyl-12-phenyl-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazine

(7aR,10R,12S)-7a,8,9,10-tetrahydro-10-phenyethynyl-12-phenyl-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 667870-41-9 (7aR,10R,12S)-10-(1H-benzotriazol-1-yl)-7a,8,9,10-tetrahydro-12-phenyl-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazine

Send

Send

Metric Ton KG G Pound L ML

Send

Send