(1S,2S)-2-((R)-1-Phenyl-ethylamino)-cyclohex-3-enecarboxylic acid benzyl ester

Base Information

Chemical Name:(1S,2S)-2-((R)-1-Phenyl-ethylamino)-cyclohex-3-enecarboxylic acid benzyl ester
CAS No.:532990-01-5
Molecular Formula:C₂₂H₂₅NO₂
Molecular Weight:335.446
Hs Code.:

Synonyms:(1S,2S)-2-((R)-1-Phenyl-ethylamino)-cyclohex-3-enecarboxylic acid benzyl ester

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Chemical Property of (1S,2S)-2-((R)-1-Phenyl-ethylamino)-cyclohex-3-enecarboxylic acid benzyl ester

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Technology Process of (1S,2S)-2-((R)-1-Phenyl-ethylamino)-cyclohex-3-enecarboxylic acid benzyl ester

There total 5 articles about (1S,2S)-2-((R)-1-Phenyl-ethylamino)-cyclohex-3-enecarboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 532989-99-4
(S)-2-[(E)-(S)-3-Phenyl-1-((R)-1-phenyl-ethylamino)-allyl]-hex-5-enoic acid benzyl ester

: 532990-01-5
(1S,2S)-2-((R)-1-Phenyl-ethylamino)-cyclohex-3-enecarboxylic acid benzyl ester

Guidance literature:: Grubbs catalyst first generation; In toluene; at 55 ℃; for 48h;
DOI:10.1002/ejoc.200390118

Reference yield:

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 532990-01-5
(1S,2S)-2-((R)-1-Phenyl-ethylamino)-cyclohex-3-enecarboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 0.33 h / 0 °C

2.1: SnCl₄; Et₃N / CH₂Cl₂ / 0.5 h / -78 °C

2.2: 25 percent / CH₂Cl₂ / -78 - 20 °C

3.1: 84 percent / chlorotrimethylsilane / CH₂Cl₂ / 48 h / 20 °C

4.1: Grubbs' catalyst / toluene / 48 h / 55 °C

With chloro-trimethyl-silane; tin(IV) chloride; triethylamine; Grubbs catalyst first generation; In dichloromethane; toluene;
DOI:10.1002/ejoc.200390118

Reference yield:

: 127759-27-7
cinnamaldehid-(R)-(+)-α-methylbenzylamine derived imine

: 532990-01-5
(1S,2S)-2-((R)-1-Phenyl-ethylamino)-cyclohex-3-enecarboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: SnCl₄; Et₃N / CH₂Cl₂ / 0.5 h / -78 °C

1.2: 25 percent / CH₂Cl₂ / -78 - 20 °C

2.1: 84 percent / chlorotrimethylsilane / CH₂Cl₂ / 48 h / 20 °C

3.1: Grubbs' catalyst / toluene / 48 h / 55 °C

With chloro-trimethyl-silane; tin(IV) chloride; triethylamine; Grubbs catalyst first generation; In dichloromethane; toluene;
DOI:10.1002/ejoc.200390118