[4-{2-[1-(3-carbamoyl-4-cyclohexylmethoxy-phenyl)-1-methyl-ethylcarbamoyl]-ethyl}-2-(diethoxy-phosphoryl)-phenoxy]-acetic acid tert-butyl ester

Base Information

Chemical Name:[4-{2-[1-(3-carbamoyl-4-cyclohexylmethoxy-phenyl)-1-methyl-ethylcarbamoyl]-ethyl}-2-(diethoxy-phosphoryl)-phenoxy]-acetic acid tert-butyl ester
CAS No.:805240-47-5
Molecular Formula:C₃₆H₅₃N₂O₉P
Molecular Weight:688.799
Hs Code.:

[4-{2-[1-(3-carbamoyl-4-cyclohexylmethoxy-phenyl)-1-methyl-ethylcarbamoyl]-ethyl}-2-(diethoxy-phosphoryl)-phenoxy]-acetic acid <i>tert</i>-butyl ester

Synonyms:[4-{2-[1-(3-carbamoyl-4-cyclohexylmethoxy-phenyl)-1-methyl-ethylcarbamoyl]-ethyl}-2-(diethoxy-phosphoryl)-phenoxy]-acetic acid tert-butyl ester

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Chemical Property of [4-{2-[1-(3-carbamoyl-4-cyclohexylmethoxy-phenyl)-1-methyl-ethylcarbamoyl]-ethyl}-2-(diethoxy-phosphoryl)-phenoxy]-acetic acid tert-butyl ester

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Technology Process of [4-{2-[1-(3-carbamoyl-4-cyclohexylmethoxy-phenyl)-1-methyl-ethylcarbamoyl]-ethyl}-2-(diethoxy-phosphoryl)-phenoxy]-acetic acid tert-butyl ester

There total 5 articles about [4-{2-[1-(3-carbamoyl-4-cyclohexylmethoxy-phenyl)-1-methyl-ethylcarbamoyl]-ethyl}-2-(diethoxy-phosphoryl)-phenoxy]-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 381213-67-8
(5-{2-[1-(3-carbamoyl-4-cyclohexylmethoxy-phenyl)-1-methyl-ethylcarbamoyl]-ethyl}-2-hydroxy-phenyl)-phosphonic acid diethyl ester

: 805240-47-5
[4-{2-[1-(3-carbamoyl-4-cyclohexylmethoxy-phenyl)-1-methyl-ethylcarbamoyl]-ethyl}-2-(diethoxy-phosphoryl)-phenoxy]-acetic acid tert-butyl ester

Guidance literature:: With caesium carbonate;
DOI:10.1016/S0960-894X(01)00446-2

Reference yield:

: 5597-50-2
3-(4-hydroxyphenyl)propionic acid methyl ester

: 805240-47-5
[4-{2-[1-(3-carbamoyl-4-cyclohexylmethoxy-phenyl)-1-methyl-ethylcarbamoyl]-ethyl}-2-(diethoxy-phosphoryl)-phenoxy]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / K₂CO₃ / acetonitrile

2: 65 percent / LDA / tetrahydrofuran / -78 °C

3: 90 percent / LiOH / methanol; tetrahydrofuran

4: 82 percent / EDC; 1-hydroxy-7-azabenzotriazole; NMM

5: 89 percent / Cs₂CO₃

With 4-methyl-morpholine; lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; potassium carbonate; caesium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; lithium diisopropyl amide; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1016/S0960-894X(01)00446-2

Reference yield:

: 224445-71-0
3-[4-(diethoxy-phosphoryloxy)-phenyl]-propionic acid methyl ester

: 805240-47-5
[4-{2-[1-(3-carbamoyl-4-cyclohexylmethoxy-phenyl)-1-methyl-ethylcarbamoyl]-ethyl}-2-(diethoxy-phosphoryl)-phenoxy]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / LDA / tetrahydrofuran / -78 °C

2: 90 percent / LiOH / methanol; tetrahydrofuran

3: 82 percent / EDC; 1-hydroxy-7-azabenzotriazole; NMM

4: 89 percent / Cs₂CO₃

With 4-methyl-morpholine; lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; caesium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; lithium diisopropyl amide; In tetrahydrofuran; methanol;
DOI:10.1016/S0960-894X(01)00446-2