tert-butyl (R)-4-(4-chloro-3-iodophenyl)-2-oxopyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (R)-4-(4-chloro-3-iodophenyl)-2-oxopyrrolidine-1-carboxylate
CAS No.:1252761-94-6
Molecular Formula:C₁₅H₁₇ClINO₃
Molecular Weight:421.662
Hs Code.:

Synonyms:tert-butyl (R)-4-(4-chloro-3-iodophenyl)-2-oxopyrrolidine-1-carboxylate

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Chemical Property of tert-butyl (R)-4-(4-chloro-3-iodophenyl)-2-oxopyrrolidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl (R)-4-(4-chloro-3-iodophenyl)-2-oxopyrrolidine-1-carboxylate

There total 5 articles about tert-butyl (R)-4-(4-chloro-3-iodophenyl)-2-oxopyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.3%

: 24424-99-5
di-tert-butyl dicarbonate

: 1252761-95-7
(R)-4-(4-chloro-3-iodophenyl)pyrrolidin-2-one

: 1252761-94-6
tert-butyl (R)-4-(4-chloro-3-iodophenyl)-2-oxopyrrolidine-1-carboxylate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 12h; Reagent/catalyst;
DOI:10.1021/acschemneuro.8b00038

Reference yield:

: 69308-37-8
(R)-baclofen

: 1252761-94-6
tert-butyl (R)-4-(4-chloro-3-iodophenyl)-2-oxopyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / 12 h / Reflux

2.1: guanidine nitrate; sulfuric acid / 1 h / 0 - 20 °C

3.1: ammonium chloride; zinc / tetrahydrofuran; methanol; water / 1 h / 90 °C / Reflux

4.1: sodium nitrite; hydrogenchloride / water / 0.5 h / 0 °C

4.2: 1.75 h / 0 - 20 °C

5.1: dmap; triethylamine / dichloromethane / 12 h / 0 - 20 °C

With hydrogenchloride; dmap; sulfuric acid; guanidine nitrate; ammonium chloride; acetic acid; triethylamine; zinc; sodium nitrite; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/acschemneuro.8b00038

Reference yield:

: 123632-35-9
(R)-(-)-4-(4-chlorophenyl)pyrrolidin-2-one

: 1252761-94-6
tert-butyl (R)-4-(4-chloro-3-iodophenyl)-2-oxopyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: guanidine nitrate; sulfuric acid / 1 h / 0 - 20 °C

2.1: ammonium chloride; zinc / tetrahydrofuran; methanol; water / 1 h / 90 °C / Reflux

3.1: sodium nitrite; hydrogenchloride / water / 0.5 h / 0 °C

3.2: 1.75 h / 0 - 20 °C

4.1: dmap; triethylamine / dichloromethane / 12 h / 0 - 20 °C

With hydrogenchloride; dmap; sulfuric acid; guanidine nitrate; ammonium chloride; triethylamine; zinc; sodium nitrite; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/acschemneuro.8b00038