2-[3-fluoro-4-(methylsulfonyl)-2-(trifluoromethyl)benzoyl]cyclo-hexane-1,3-dione

Base Information

Chemical Name:2-[3-fluoro-4-(methylsulfonyl)-2-(trifluoromethyl)benzoyl]cyclo-hexane-1,3-dione
CAS No.:1329602-25-6
Molecular Formula:C₁₅H₁₂F₄O₅S
Molecular Weight:380.317
Hs Code.:

Synonyms:2-[3-fluoro-4-(methylsulfonyl)-2-(trifluoromethyl)benzoyl]cyclo-hexane-1,3-dione

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Chemical Property of 2-[3-fluoro-4-(methylsulfonyl)-2-(trifluoromethyl)benzoyl]cyclo-hexane-1,3-dione

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Technology Process of 2-[3-fluoro-4-(methylsulfonyl)-2-(trifluoromethyl)benzoyl]cyclo-hexane-1,3-dione

There total 4 articles about 2-[3-fluoro-4-(methylsulfonyl)-2-(trifluoromethyl)benzoyl]cyclo-hexane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 3-fluoro-4-(methylsulfonyl)-2-(trifluoromethyl)benzoic acid

: 504-02-9
1,3-cylohexanedione

: 1329602-25-6
2-[3-fluoro-4-(methylsulfonyl)-2-(trifluoromethyl)benzoyl]cyclo-hexane-1,3-dione

Guidance literature:: 3-fluoro-4-(methylsulfonyl)-2-(trifluoromethyl)benzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 0.25h; Reflux;

1,3-cylohexanedione; With triethylamine; In dichloromethane; at 20 ℃; for 1h;

With potassium cyanide; trimethylsilyl cyanide; triethylamine; In acetonitrile; at 20 ℃;

Reference yield:

: 159329-02-9
1-bromo-3-fluoro-4-(methylsulfanyl)-2-(trifluoromethyl)benzene

: 1329602-25-6
2-[3-fluoro-4-(methylsulfonyl)-2-(trifluoromethyl)benzoyl]cyclo-hexane-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / hexane; diethyl ether / 1 h / -78 °C

1.2: -78 - 20 °C

2.1: sodium tungstate; dihydrogen peroxide; acetic acid / water / 1 h / 60 - 80 °C

3.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 0.25 h / Reflux

3.2: 1 h / 20 °C

3.3: 20 °C

With sodium tungstate; n-butyllithium; oxalyl dichloride; dihydrogen peroxide; acetic acid; N,N-dimethyl-formamide; In diethyl ether; hexane; dichloromethane; water;

Reference yield:

: 159329-01-8
3-fluoro-4-(methylsulphenyl)-2-trifluoromethylbenzoic acid

: 1329602-25-6
2-[3-fluoro-4-(methylsulfonyl)-2-(trifluoromethyl)benzoyl]cyclo-hexane-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tungstate; dihydrogen peroxide; acetic acid / water / 1 h / 60 - 80 °C

2.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 0.25 h / Reflux

2.2: 1 h / 20 °C

2.3: 20 °C

With sodium tungstate; oxalyl dichloride; dihydrogen peroxide; acetic acid; N,N-dimethyl-formamide; In dichloromethane; water;