1-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)-4-(2-(4-nitrophenyl)ethyl)piperazine

Base Information

Chemical Name:1-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)-4-(2-(4-nitrophenyl)ethyl)piperazine
CAS No.:174609-63-3
Molecular Formula:C₂₅H₂₉N₇O₂
Molecular Weight:459.551
Hs Code.:

Synonyms:1-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)-4-(2-(4-nitrophenyl)ethyl)piperazine

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Chemical Property of 1-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)-4-(2-(4-nitrophenyl)ethyl)piperazine

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Technology Process of 1-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)-4-(2-(4-nitrophenyl)ethyl)piperazine

There total 4 articles about 1-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)-4-(2-(4-nitrophenyl)ethyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 5339-26-4
(4-nitrophenyl)ethyl bromide

: 174609-58-6
1-[3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl]-4H-piperazine

: 174609-63-3
1-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)-4-(2-(4-nitrophenyl)ethyl)piperazine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 18h; Ambient temperature;
DOI:10.1021/jm980569z

Reference yield: 52.0%

: 174609-63-3
1-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)-4-(2-(4-nitrophenyl)ethyl)piperazine

Guidance literature:

Reference yield:

: 78643-42-2
5-bromopentanal dimethyl acetal

: 174609-63-3
1-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)-4-(2-(4-nitrophenyl)ethyl)piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / NaI, Na₂CO₃ / 1,2-dimethoxy-ethane / 3 h / 100 °C

2: 44 percent / 4 percent H₂SO₄ / 48 h / Heating

3: 52 percent / K₂CO₃ / dimethylformamide / 18 h / Ambient temperature

With sulfuric acid; sodium carbonate; potassium carbonate; sodium iodide; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980569z