3-(4-chloro-phenyl)-1-(4-methoxy-phenyl)-4-p-tolyl-1H-pyrazole

Base Information

• Chemical Name: 3-(4-chloro-phenyl)-1-(4-methoxy-phenyl)-4-p-tolyl-1H-pyrazole
• CAS No.: 1016169-41-7
• Molecular Formula: C₂₃H₁₉ClN₂O
• Molecular Weight: 374.87
• Mol file: 1016169-41-7.mol

Synonyms:3-(4-chloro-phenyl)-1-(4-methoxy-phenyl)-4-p-tolyl-1H-pyrazole

Chemical Property of 3-(4-chloro-phenyl)-1-(4-methoxy-phenyl)-4-p-tolyl-1H-pyrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-chloro-phenyl)-1-(4-methoxy-phenyl)-4-p-tolyl-1H-pyrazole

There total 4 articles about 3-(4-chloro-phenyl)-1-(4-methoxy-phenyl)-4-p-tolyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(E)-2-(4-methylphenyl)-1-nitroethene (101671-00-5,5153-68-4) + N-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-N'-(4-methoxy-phenyl)-hydrazine (103185-60-0) → 3-(4-chloro-phenyl)-1-(4-methoxy-phenyl)-4-p-tolyl-1H-pyrazole (1016169-41-7)

Guidance literature:

N-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-N'-(4-methoxy-phenyl)-hydrazine; With potassium tert-butylate; In tetrahydrofuran; at -78 ℃; for 0.166667h; Inert atmosphere;

(E)-2-(4-methylphenyl)-1-nitroethene; at -78 ℃; for 0.25h; Inert atmosphere;

With trifluoroacetic acid; In tetrahydrofuran; at -78 - 20 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1021/ol800200j

Reference yield:

4-methyl-benzaldehyde (104-87-0) → 3-(4-chloro-phenyl)-1-(4-methoxy-phenyl)-4-p-tolyl-1H-pyrazole (1016169-41-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 2 h / 20 °C / Inert atmosphere

2.1: potassium tert-butylate / 0.5 h / -78 °C / Inert atmosphere

2.2: 12 h / -78 - 20 °C / Inert atmosphere

2.3: 24 h / -78 - 20 °C / Inert atmosphere

With potassium tert-butylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In acetonitrile;

DOI:10.1002/ejoc.201500562

Reference yield:

4-chlorobenzaldehyde (104-88-1) → 3-(4-chloro-phenyl)-1-(4-methoxy-phenyl)-4-p-tolyl-1H-pyrazole (1016169-41-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2.1: potassium tert-butylate / 0.5 h / -78 °C / Inert atmosphere

2.2: 12 h / -78 - 20 °C / Inert atmosphere

2.3: 24 h / -78 - 20 °C / Inert atmosphere

With potassium tert-butylate; In tetrahydrofuran;

DOI:10.1002/ejoc.201500562

upstream raw materials:

(E)-2-(4-methylphenyl)-1-nitroethene

N-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-N'-(4-methoxy-phenyl)-hydrazine

4-methyl-benzaldehyde

4-chlorobenzaldehyde