(2-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-ylamino)pyridin-4-yl)methanol

Base Information

Chemical Name:(2-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-ylamino)pyridin-4-yl)methanol
CAS No.:1365989-46-3
Molecular Formula:C₁₈H₁₂Cl₂N₄OS
Molecular Weight:403.291
Hs Code.:

Synonyms:(2-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-ylamino)pyridin-4-yl)methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-ylamino)pyridin-4-yl)methanol

Chemical Property:

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Technology Process of (2-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-ylamino)pyridin-4-yl)methanol

There total 7 articles about (2-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-ylamino)pyridin-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1242254-41-6
4-chloro-2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridine

: 105250-17-7
2-amino-4-hydroxymethylpyridine

: 1365989-46-3
(2-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-ylamino)pyridin-4-yl)methanol

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 140 ℃; for 2h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 4659-45-4
2,6-Dichlorobenzoyl chloride

: 1365989-46-3
(2-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-ylamino)pyridin-4-yl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / 1,4-dioxane / 18 h / Reflux

2.1: thionyl chloride / 18 h / Reflux

3.1: thiourea; pyridine / isopropyl alcohol / 3.5 h / Inert atmosphere; Reflux

3.2: 2 h / Heating

4.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 2 h / 140 °C / Inert atmosphere; Microwave irradiation

With pyridine; thionyl chloride; caesium carbonate; triethylamine; thiourea; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; isopropyl alcohol;

Reference yield:

: 628691-93-0
2-chloro-3-fluoro-pyridine-4-carboxylic acid

: 1365989-46-3
(2-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-ylamino)pyridin-4-yl)methanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: diphenyl phosphoryl azide / toluene / 3 h / 110 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

2.2: NH₂ cartridge

3.1: triethylamine / 1,4-dioxane / 18 h / Reflux

4.1: thionyl chloride / 18 h / Reflux

5.1: thiourea; pyridine / isopropyl alcohol / 3.5 h / Inert atmosphere; Reflux

5.2: 2 h / Heating

6.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 2 h / 140 °C / Inert atmosphere; Microwave irradiation

With pyridine; thionyl chloride; diphenyl phosphoryl azide; caesium carbonate; triethylamine; thiourea; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane; isopropyl alcohol; toluene;