Technology Process of (3aS,7aS)-1-Benzyl-7a-methyl-1,3a,4,7a-tetrahydro-pyrano[4,3-d]oxazol-2-one
There total 6 articles about (3aS,7aS)-1-Benzyl-7a-methyl-1,3a,4,7a-tetrahydro-pyrano[4,3-d]oxazol-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) Ti(O-i-Pr)4, D-(-)-diisopropyl tartrate, cumene hydroperoxide, molecular sieves, 2.) Ti(O-i-Pr)4 / 1.) CH2Cl2, -25 deg C, 3 h, 2.) 20 deg C, 2 h
2: 90 percent / imidazole / dimethylformamide / 1.) 0 deg C, 2 h, 2.) 20 deg C, 8 h
3: 99 percent / aq. K2CO3 / toluene / 20 °C
4: 96 percent / TBAF / tetrahydrofuran / 0.75 h / 0 °C
5: 1.) (THF)W(CO)5, 2.) Et3N / 1.) 20 deg C, 48 h, 2.) THF, Et2O, 20 deg C, 1 h
With
1H-imidazole; titanium(IV) isopropylate; molecular sieve; tungsten pentacarbonyl tetrahydrofuran; Cumene hydroperoxide; tetrabutyl ammonium fluoride; potassium carbonate; D-(-)-diisopropyl tartrate; triethylamine;
In
tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(97)00366-9
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) Ti(O-i-Pr)4, D-(-)-diisopropyl tartrate, cumene hydroperoxide, molecular sieves, 2.) Ti(O-i-Pr)4 / 1.) CH2Cl2, -25 deg C, 3 h, 2.) 20 deg C, 2 h
2: 90 percent / imidazole / dimethylformamide / 1.) 0 deg C, 2 h, 2.) 20 deg C, 8 h
3: 99 percent / aq. K2CO3 / toluene / 20 °C
4: 96 percent / TBAF / tetrahydrofuran / 0.75 h / 0 °C
5: 1.) (THF)W(CO)5, 2.) Et3N / 1.) 20 deg C, 48 h, 2.) THF, Et2O, 20 deg C, 1 h
With
1H-imidazole; titanium(IV) isopropylate; molecular sieve; tungsten pentacarbonyl tetrahydrofuran; Cumene hydroperoxide; tetrabutyl ammonium fluoride; potassium carbonate; D-(-)-diisopropyl tartrate; triethylamine;
In
tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(97)00366-9
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 90 percent / imidazole / dimethylformamide / 1.) 0 deg C, 2 h, 2.) 20 deg C, 8 h
2: 99 percent / aq. K2CO3 / toluene / 20 °C
3: 96 percent / TBAF / tetrahydrofuran / 0.75 h / 0 °C
4: 1.) (THF)W(CO)5, 2.) Et3N / 1.) 20 deg C, 48 h, 2.) THF, Et2O, 20 deg C, 1 h
With
1H-imidazole; tungsten pentacarbonyl tetrahydrofuran; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine;
In
tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(97)00366-9
