O-(2-chlorophenyl)-N^α-(9-fluorenylmethoxycarbonyl-serin-3-yl allyl ester)-(2',3'-di-O-acetyluridin-5'-yl)phosphate

Base Information

• Chemical Name: O-(2-chlorophenyl)-N^α-(9-fluorenylmethoxycarbonyl-serin-3-yl allyl ester)-(2',3'-di-O-acetyluridin-5'-yl)phosphate
• CAS No.: 537677-40-0
• Molecular Formula: C₄₀H₃₉ClN₃O₁₅P
• Molecular Weight: 868.188

Synonyms:O-(2-chlorophenyl)-N^α-(9-fluorenylmethoxycarbonyl-serin-3-yl allyl ester)-(2',3'-di-O-acetyluridin-5'-yl)phosphate

Chemical Property of O-(2-chlorophenyl)-N^α-(9-fluorenylmethoxycarbonyl-serin-3-yl allyl ester)-(2',3'-di-O-acetyluridin-5'-yl)phosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O-(2-chlorophenyl)-N^α-(9-fluorenylmethoxycarbonyl-serin-3-yl allyl ester)-(2',3'-di-O-acetyluridin-5'-yl)phosphate

There total 4 articles about O-(2-chlorophenyl)-N^α-(9-fluorenylmethoxycarbonyl-serin-3-yl allyl ester)-(2',3'-di-O-acetyluridin-5'-yl)phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine (73724-45-5) → O-(2-chlorophenyl)-Nα-(9-fluorenylmethoxycarbonyl-serin-3-yl allyl ester)-(2',3'-di-O-acetyluridin-5'-yl)phosphate (537677-40-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: silver carbonate / dimethylformamide / 0.25 h / 20 °C

1.2: 89 percent / dimethylformamide / 2.5 h / 20 °C

2.1: 3.8 g / dioxane; pyridine / 2 h / 20 °C

With silver carbonate; In 1,4-dioxane; pyridine; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(03)00042-5

Reference yield:

N-(9-fluorenylmethoxycarbonyl)-L-serine allyl ester (136497-85-3) + Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-[(benzotriazol-1-yloxy)-(2-chloro-phenoxy)-phosphoryloxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester → O-(2-chlorophenyl)-Nα-(9-fluorenylmethoxycarbonyl-serin-3-yl allyl ester)-(2',3'-di-O-acetyluridin-5'-yl)phosphate (537677-40-0)

Guidance literature:

In 1,4-dioxane; pyridine; at 20 ℃; for 2h;

DOI:10.1016/S0040-4020(03)00042-5

Reference yield:

bis(benzotriazol-1-yl)(2-chlorophenyl)phosphate (80817-46-5) → O-(2-chlorophenyl)-Nα-(9-fluorenylmethoxycarbonyl-serin-3-yl allyl ester)-(2',3'-di-O-acetyluridin-5'-yl)phosphate (537677-40-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; dioxane / 1 h

2: 3.8 g / dioxane; pyridine / 2 h / 20 °C

In 1,4-dioxane; pyridine;

DOI:10.1016/S0040-4020(03)00042-5

upstream raw materials:

N-(9-fluorenylmethoxycarbonyl)-L-serine allyl ester

bis(benzotriazol-1-yl)(2-chlorophenyl)phosphate

N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine

2',3'-di-O-acetyl-uridine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 537677-40-0 O-(2-chlorophenyl)-N^α-(9-fluorenylmethoxycarbonyl-serin-3-yl allyl ester)-(2',3'-di-O-acetyluridin-5'-yl)phosphate

Send

Send

Metric Ton KG G Pound L ML

Send

Send