80817-46-5

Upstream product

• 2592-95-2 benzotriazol-1-ol 
• 15074-54-1 2-chlorophenyl dichlorophosphate 

Downstream Products

• 75251-83-1 5'-O-dimethoxytritylthymidylyl-(3',5')-(o-chlorophenyl)-thymidylyl-3'-β-cyanoethyl(o-chlorophenyl)phosphate 
• 99681-86-4 Benzotriazol-1-yl-phosphonic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 
• 75269-16-8 <(MeO)2Tr>bzA_dΦbzA_dΦ(CNEt) 
• 91592-78-8 N⁽⁶⁾-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)adenosine 3'-(benzotrizol-1-yl 2-chlorophenylphosphate) 
• 80817-34-1 N-6-benzoyl-5'-O-(dimethoxytrityl)-2'-deoxyadenosine 3'-(o-chlorophenyl β-cyanoethyl phosphate) 
• 80817-36-3 N-2-isobutyryl-5'-O-(dimethoxytrityl)-2'-deoxyguanosine 3'-(o-chlorophenyl β-cyanoethyl phosphate) 
• 93183-95-0 5'-O-dimethoxytrityl-N²-isobutyryl-O⁶-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(2-chlorophenyl,2-cyanoethyl)phosphate 
• 124814-86-4 Phosphoric acid benzotriazol-1-yl ester (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 
• 101364-55-0 C₃₉H₄₄Cl₂N₄O₂₀P₂ 
• 196200-70-1 C₆₈H₈₂ClN₄O₂₂P 
• 130974-97-9 Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 
• 80817-53-4 Phosphoric acid (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 2-cyano-ethyl ester 
• 80824-67-5 Phosphoric acid (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 2-(4-nitro-phenyl)-ethyl ester 
• 80824-68-6 Phosphoric acid (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 5-chloro-quinolin-8-yl ester 

Relevant academic research and scientific papers

Preparation of a disulfide-linked precipitative soluble support for solution-phase synthesis of trimeric oligodeoxyribonucleotide 3-(2-chlorophenylphosphate) building blocks

The preparation of a disulfide-tethered precipitative soluble support and its use for solution-phase synthesis of tnmenc oligodeoxy-ribonucleotide 3′-(2-chlorophenylphosphate) building blocks is described. To obtain the building blocks, N-acyl protected 2

Synthesis of short oligodeoxyribonucleotides by phosphotriester chemistry on a precipitative tetrapodal support

Short oligodeoxyribonucleotides have been assembled from appropriately protected nucleoside 3′-(benzotriazol-1-yl 2-chlorophenyl phosphate) derivatives on hundred-milligram scales on a soluble tetrakis-O-(4- azidomethylphenyl)pentaerythritol support beari

New approach for the synthesis of c-di-GMP and its analogues

The synthesis of cyclic bis(3′-5′)diguanylic acid (c-di-GMP) by using a new flexible approach is reported. The flexibility of the method is exemplified by the synthesis of base-modified analogues that will find applications in the elucidation of c-di-GMP

REACTION BETWEEN NUCLEOSIDE BASE AND THE PHOSPHORYLATING AGENT DERIVED FROM 1-HYDROXYBENZOTRIAZOLE AND 2-CHLOROPHENYL PHOSPHORODICHLORIDATE

In the presence of 1-methylimidazole, 2-N-acyl guanine (as in 4a), thymine (as in 5a), and uracil (as in 5b) residues react readily with the phosphorylating agent derived from 2-chlorophenyl phosphorodichloridate (1a) and 1-hydroxybenzotriazole.

A convenient method for the preparation of terminal methyl phosphates of nucleic acids

The reagent 2-chlorophenyl bis(1-benzotriazolyl) phosphate has been used for the preparation of 5'-O-(methyl phosphate) esters of the dimers TpT, UpU, Upm62A and m62ApU, as well as 3',5'-bis-O-(methyl phosphate)esters of uridine (U)

SYNTHESIS OF A LIPOTEICHOIC ACID-CARRIER FRAGMENT OF Staphylococcus aureus

A lipoteichoic acid-carrier fragment containing three glycerol units and one glycolipid unit was synthesized by use of the bifunctional phosphorylating reagents bis(1-benzotriazolyl) 2,2,2-tribromoethyl and 2-chlorophenyl phosphates.Protection of the sn-g

Improved Synthesis of Oligodeoxyribonucleotides by Solid-Phase Phosphotriester Method Utilizing O6--2'-deoxyguanosine Derivatives

The synthesis of oligodeoxyribonucleotides on a cross-linked polystyrene solid support utilizing stable mono- and dinucleotide phosphotriester building blocks is presented.The use of O6--2'deoxyguanosine derivatives yields cleaner DNA fragments by supressing side reactions.Modifications improving the phosphotriester methodology are presented.The purification methods and analysis of synthetic oligodeoxyribonucleotides are described.

Synthesis of a teichoic acid fragment of Bacillus subtilis using a modified phosphotriester approach

The synthesis of a teichoic acid fragment (i.e. compound 8e), containing three 3-O-(β-glucopyranosyl)-sn-glycerol residues connected via two phosphodiester linkages, is described.The assemblage of the teichoic acid fragment was effected using a modified p

A NEW APPROACH TO THE SYNTHESIS OF PHOSPHOTRIESTER INTERMEDIATES OF NUCLEOSIDES AND NUCLEIC ACIDS

Aryl phosphorodichloridates can be converted by means of 1-hydroxybenzotriazole into an effective phosphorylating agent, which can be applied to the synthesis of phosphotriester intermediates of nucleic acids.