(1R,2S)-2-methyl-3-methylene-1-(4,5,6-trimethoxy-3',4'-methylenedioxybiphenyl-2-yl)butane-1,4-diol

Base Information

Chemical Name:(1R,2S)-2-methyl-3-methylene-1-(4,5,6-trimethoxy-3',4'-methylenedioxybiphenyl-2-yl)butane-1,4-diol
CAS No.:1441119-50-1
Molecular Formula:C₂₂H₂₆O₇
Molecular Weight:402.444
Hs Code.:

Synonyms:(1R,2S)-2-methyl-3-methylene-1-(4,5,6-trimethoxy-3',4'-methylenedioxybiphenyl-2-yl)butane-1,4-diol

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Chemical Property of (1R,2S)-2-methyl-3-methylene-1-(4,5,6-trimethoxy-3',4'-methylenedioxybiphenyl-2-yl)butane-1,4-diol

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Technology Process of (1R,2S)-2-methyl-3-methylene-1-(4,5,6-trimethoxy-3',4'-methylenedioxybiphenyl-2-yl)butane-1,4-diol

There total 5 articles about (1R,2S)-2-methyl-3-methylene-1-(4,5,6-trimethoxy-3',4'-methylenedioxybiphenyl-2-yl)butane-1,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1441119-48-7
(1R,2S)-2-methyl-3-[(triisopropylsilyloxy)methyl]-1-(4,5,6-trimethoxy-3',4'-methylenedioxybiphenyl-2-yl)but-3-en-1-ol

: 1441119-50-1
(1R,2S)-2-methyl-3-methylene-1-(4,5,6-trimethoxy-3',4'-methylenedioxybiphenyl-2-yl)butane-1,4-diol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1002/ejoc.201201247

Reference yield:

: 73252-54-7
(2-bromo-3,4,5-trimethoxyphenyl)methanol

: 1441119-50-1
(1R,2S)-2-methyl-3-methylene-1-(4,5,6-trimethoxy-3',4'-methylenedioxybiphenyl-2-yl)butane-1,4-diol

Guidance literature:: Multi-step reaction with 4 steps

1: CyJohnPhos; potassium phosphate; palladium diacetate / toluene / 10 h / 80 - 90 °C / Inert atmosphere

2: potassium tert-butylate / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

3: n-butyllithium; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline] / diethyl ether; hexane / 4 h / -78 °C / Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With potassium phosphate; n-butyllithium; potassium tert-butylate; tetrabutyl ammonium fluoride; palladium diacetate; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline]; CyJohnPhos; In tetrahydrofuran; diethyl ether; hexane; toluene; 1: |Suzuki Coupling / 2: |Williamson Ether Synthesis / 3: |[2,3]-Wittig Rearrangement;
DOI:10.1002/ejoc.201201247

Reference yield:

: (E)-2-(triisopropylsilyloxymethyl)-1-[(4,5,6-trimethoxy-3',4'-methylenedioxybiphenyl-2-yl)methoxy]but-2-ene

: 1441119-50-1
(1R,2S)-2-methyl-3-methylene-1-(4,5,6-trimethoxy-3',4'-methylenedioxybiphenyl-2-yl)butane-1,4-diol

Guidance literature:: Multi-step reaction with 2 steps

1: n-butyllithium; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline] / diethyl ether; hexane / 4 h / -78 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With n-butyllithium; tetrabutyl ammonium fluoride; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline]; In tetrahydrofuran; diethyl ether; hexane; 1: |[2,3]-Wittig Rearrangement;
DOI:10.1002/ejoc.201201247