73252-54-7

Basic information

• Product Name: (2-bromo-3,4,5-trimethoxyphenyl)methanol
• CAS NO: 73252-54-7
• Molecular Formula: C₁₀H₁₃BrO₄
• Molecular Weight: 277.1118
• Mol File: 73252-54-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 351.7°C at 760 mmHg
• Flash Point: 166.5°C
• Density: 1.447g/cm³
• Vapor Pressure: 1.5E-05mmHg at 25°C
• Refractive Index: 1.543
• CAS DataBase Reference: (2-bromo-3,4,5-trimethoxyphenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-bromo-3,4,5-trimethoxyphenyl)methanol(73252-54-7)
• EPA Substance Registry System: (2-bromo-3,4,5-trimethoxyphenyl)methanol(73252-54-7)

Safety Data

• Hazardous Substances Data: 73252-54-7(Hazardous Substances Data)

Usage

General Description

(2-bromo-3,4,5-trimethoxyphenyl)methanol is a chemical compound with a molecular formula C10H13BrO4. It is a derivative of phenylmethanol and contains a bromine atom and three methoxy groups. (2-bromo-3,4,5-trimethoxyphenyl)methanol is used in organic synthesis and pharmaceutical research. It has also been studied for its potential biological activities, including its antioxidant and anticancer properties. Additionally, it has been investigated as a potential building block in the synthesis of new chemical compounds with pharmacological and medical applications. Overall, (2-bromo-3,4,5-trimethoxyphenyl)methanol is a versatile compound that has potential applications in various fields of chemistry and medicine.

Upstream product

• 35274-53-4 2-bromo-3,4,5-tri-methoxybenzaldehyde 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 118-41-2 Eudesmic acid 
• 3840-31-1 (3,4,5-trimethoxyphenyl)methanol 

Downstream Products

• 848694-16-6 2-bromo-3,4,5-trimethoxybenzyl chloride 
• 139006-76-1 (+)-eupomatilone 2 
• 1401416-09-8 ethyl (2E)-3-{6-[(3-ethoxy-3-oxopropoxy)methyl]-2,3,4-trimethoxyphenyl}acrylate 
• 1401416-21-4 tert-butyl (2E)-3-{6-[(3-tert-butoxy-3-oxopropoxy)methyl]-2,3,4-trimethoxyphenyl}acrylate 
• 1441119-48-7 (1R,2S)-2-methyl-3-[(triisopropylsilyloxy)methyl]-1-(4,5,6-trimethoxy-3',4'-methylenedioxybiphenyl-2-yl)but-3-en-1-ol 
• 1441119-50-1 (1R,2S)-2-methyl-3-methylene-1-(4,5,6-trimethoxy-3',4'-methylenedioxybiphenyl-2-yl)butane-1,4-diol 
• 1441119-44-3 (2-(benzo[d][1,3]dioxol-5-yl)-3,4,5-trimethoxyphenyl)methanol 
• 130611-34-6 2-bromo-1-<(tert-butyldimethylsiloxy)methyl>-3,4,5-trimethoxybenzene 

Relevant articles and documents

Synthesis of polymethoxy-substituted triazolobenzoxazepines

A new approach has been proposed for the synthesis of polymethoxy-substituted [1,2,3]triazolo-[1,5-a][4,1]benzoxazepines starting from 2-bromo-4,5-dimethoxy- and 2-bromo-3,4,5-dimethoxybenzyl alcohols with thermal [3 + 2]-dipolar cycloaddition as the key stage.

Sequential one-pot method for oxy-Michael addition, Heck coupling, and degradation followed by condensation: Facile synthesis of 2-benzoxepin-3(1H)- ones Dedicated to the memory of my teacher Professor P.V. Subba Rao, Department of Chemistry, Andhra University, Visakhapatnam

A sequential one-pot intermolecular oxy-Michael addition, intermolecular Heck coupling, and intramolecular degradation (retro-oxy-Michael addition) followed by condensation method has been developed for the synthesis of interesting 2-benzoxepin-3(1H)-ones. Significantly, the 2-benzoxepin-3(1H)-ones form the core quantum of biologically vital natural products. The initial oxy-Michael addition and Heck coupling steps involve a straight forward construction of C-O and C-C bonds, whereas, the final condensation step follows a novel mechanistic path via intramolecular degradation, double bond isomerization, and intramolecular condensation. Notably, a remarkable solvent effect has been observed in-order to promote the final intramolecular condensation.

A novel anionic domino process for the synthesis of o-cyanoaryl-methylthio/ alkyl/aryl/heteroaryl acetylenes

A novel unexpected anionic domino process involving n-BuLi-induced rearrangement of 3,3-bis(methylthio) or 3-methylthio-3-aryl heteroaryl. alkyl-o-bromoarylacrylonitriles to ocyanoarylacetylenes in synthetically useful yields has been reported. The scope and generality of the reaction has been examined, and a possible mechanism has been proposed.