2-(3-(5-(5,6-dimethoxypyridin-3-yl)-1-oxoisoindolin-2-yl)phenyl)acetonitrile

Base Information

Chemical Name:2-(3-(5-(5,6-dimethoxypyridin-3-yl)-1-oxoisoindolin-2-yl)phenyl)acetonitrile
CAS No.:1315534-54-3
Molecular Formula:C₂₃H₁₉N₃O₃
Molecular Weight:385.422
Hs Code.:

Synonyms:2-(3-(5-(5,6-dimethoxypyridin-3-yl)-1-oxoisoindolin-2-yl)phenyl)acetonitrile

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Chemical Property of 2-(3-(5-(5,6-dimethoxypyridin-3-yl)-1-oxoisoindolin-2-yl)phenyl)acetonitrile

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Technology Process of 2-(3-(5-(5,6-dimethoxypyridin-3-yl)-1-oxoisoindolin-2-yl)phenyl)acetonitrile

There total 4 articles about 2-(3-(5-(5,6-dimethoxypyridin-3-yl)-1-oxoisoindolin-2-yl)phenyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1083168-92-6
2,3-dimethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

: C₁₆H₁₁BrN₂O

: 1315534-54-3
2-(3-(5-(5,6-dimethoxypyridin-3-yl)-1-oxoisoindolin-2-yl)phenyl)acetonitrile

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In water; dimethyl sulfoxide; at 100 ℃; for 0.166667h; Inert atmosphere; Sealed tube; Microwave irradiation;
DOI:10.1021/acs.jmedchem.8b00085

Reference yield:

: 4623-24-9
2-(3-aminophenyl)acetonitrile

: 1315534-54-3
2-(3-(5-(5,6-dimethoxypyridin-3-yl)-1-oxoisoindolin-2-yl)phenyl)acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 0.42 h / 110 °C / Sealed tube; Microwave irradiation

2: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide; water / 0.17 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In water; dimethyl sulfoxide; N,N-dimethyl-formamide; 2: |Suzuki-Miyaura Coupling;
DOI:10.1021/acs.jmedchem.8b00085

Reference yield:

: 78471-43-9
methyl 4-bromo-2-(bromomethyl)benzoate

: 1315534-54-3
2-(3-(5-(5,6-dimethoxypyridin-3-yl)-1-oxoisoindolin-2-yl)phenyl)acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 0.42 h / 110 °C / Sealed tube; Microwave irradiation

2: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide; water / 0.17 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In water; dimethyl sulfoxide; N,N-dimethyl-formamide; 2: |Suzuki-Miyaura Coupling;
DOI:10.1021/acs.jmedchem.8b00085