METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE

Base Information

• Chemical Name: METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE
• CAS No.: 78471-43-9
• Molecular Formula: C9H8Br2O2
• Molecular Weight: 307.969
• Hs Code.: 2916399090
• Mol file: 78471-43-9.mol

Synonyms:4-Bromo-2-bromomethylbenzoicacid methyl ester;Methyl 4-bromo-2-(bromomethyl)benzoate;

Chemical Property of METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 76-78℃
• Boiling Point: 364.267 °C at 760 mmHg
• Flash Point: 174.103 °C
• PSA: 26.30000
• Density: 1.78 g/cm³
• LogP: 3.13060
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

99% ^*data from raw suppliers

Methyl 4-Bromo-2-(bromomethyl)benzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 4-bromo-2-(bromomethyl)benzoate is used as pharmaceutical intermediate.

Technology Process of METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE

There total 6 articles about METHYL 4-BROMO-2-BROMOMETHYL-BENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-bromo-2-methyl-benzoic acid methyl ester (99548-55-7) → methyl 4-bromo-2-(bromomethyl)benzoate (78471-43-9)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In benzene; Reflux;

DOI:10.1016/j.bmcl.2015.01.035

Reference yield: 97.0%

→ methyl 4-bromo-2-(bromomethyl)benzoate (78471-43-9)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 3h; Reflux;

Reference yield: 53.0%

4-bromo-2-methyl-benzoic acid methyl ester (99548-55-7) → methyl 4-bromo-2- (dibromomethyl)benzoate + methyl 4-bromo-2-(bromomethyl)benzoate (78471-43-9)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); Reflux;

upstream raw materials:

4-bromo-2-methyl-benzoic acid methyl ester

4-bromo-2-methylbenzoic acid

tungsten

methanol

Downstream raw materials:

5-bromoisoindolin-1-one

methyl 2-(5-bromo-1-oxoisoindolin-2-yl)-2-phenyl acetate

Methyl 4-bromo-2-phenylsulphenylmethylbenzoate

2-phenoxy-4-bromobenzoic acid

Refernces

• 1、 -. "PROCESSES FOR PREPARING 2-(4-CHLOROPHENYL)-N-((2-(2,6-DIOXOPIPERIDIN-3-YL)-1-OXOISOINDOLIN-5-YL)METHYL)-2,2-DIFLUOROACETAMIDE". Paragraph 0191. . Retrieved 2021/06/11.
• 2、 Chen, Peng-Fei,Wang, Binju,Wu, Peng,Ye, Long-Wu,Zhou, Bo. "Br?nsted Acid Catalyzed Dearomatization by Intramolecular Hydroalkoxylation/Claisen Rearrangement: Diastereo- and Enantioselective Synthesis of Spirolactams". supporting information. p. 27164 - 27170. Retrieved 2021/11/22.